Name:Longhua Zhang(张隆华), Ph.D.
Address:School of Life Sciences, University of Science and

Technology of China, 443 Huangshan Street, 

Hefei City, Anhui 230027, P.R.China
1996 - 2000University of Science and Technology of China, Biology, B.S.
2000 - 2006University of Science and Technology of China, Biophysics/Neuroscience, Ph.D
2006 - 2010University of Maryland, Baltimore, School of Medicine, Postdoctoral fellow
2011 - presentUniversity of Science and Technology of China, School of Life Sciences, Associated Professor
Structural bases of interaction modes between modulators and membrane proteins. 
Dynamic conformational changes of membrane proteins revealed by fluorescence and other biophysic approaches.
1.Zhang M, Wen M, Xiong Y, Zhang L(*), Tian C(*). In cell measurement of fluorescent lifetime imaging microscopy revealed C-terminal conformation changes of Ferroportin upon addition of Mn2+, Chinese Chem Lett, 2018, 29: 1509-1512.
2.Yu M, Liu S, Sun P, Pan H, Tian C(*), Zhang L(*). Peptide Toxins and small-molecule blockers of BK channels, Acta Pharmacol Sin, 2016, 37(1):56-66.
3.Liu S, Lv P, Li D, Guo X, Zhang B, Yu M, Li D, Xiong Y, Zhang L(*), Tian C(*). K(+) preference at the NaK channel entrance revealed by fluorescence lifetime and anisotropy analysis of site-specifically incorporated (7-hydroxycoumarin-4-yl) ethylglycine, Chem Commun (Camb), 2015, 51(88):15971-15974.
4.Sun P, Wu F, Wen M, Yang X, Wang C, Li Y, He S, Zhang L(*), Zhang Y(*), Tian C(*). A distinct three-helix centipede toxin SSD609 inhibits I(ks) channels by interacting with the KCNE1 auxiliary subunit, Sci Rep, 2015, 5: 13399.
5.Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L(*), Tian C(*). Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells, Chem Commun (Camb), 2015, 51(38):8153-8156.
6.Yu L, Wang W, Ling S, He Y, Xiao L, Wu K, Zhang L(*), Tian C(*). Distance measurement between two flexible sites in proteins in high viscosity medium at physiological temperature using continuous wave EPR, Protein Cell, 2014, 5(5):334-337.
7.Zhang L, Alger BE(*). Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome, J Neurosci, 2010, 30(16):5724-9.
8.Edward DA, Zhang L, Alger BE(*). Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus, Proc Natl Acad Sci U S A, 2008, 105(23):8142-8147.
9.Zhang L, Gong N, Fei D, Xu L(*), XU T(*).Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology, 2008, 33(3):701-711.

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