Name:Zhong Zhao
Address:Huangshan Road 443, Hefei 230027 China
Tel:+86 551 63600640
Fax:+86 551 63600640
1987-1991B.S. in Cell Biology from the Lanzhou University
1991-1994M.S. in Cell Biology from the Lanzhou University
2000-2003Ph. D. in Botany from the Fudan University
2003-2005Postdoc at the Institut de Biologie Moléculaire des Plantes  (CNRS), Strasbourg, France
2006-2009Postdoc at the Max-Planck Institute for Developmental Biology, Germany
2009-2011Senior researcher in the Department of Stem Cell Biology in Heidelberg University, Germany
2011-nowFull professor in the School of Life Sciences at the University of Science and Technology of China
In contrast to most animals, plants maintain pluripotent stem cells throughout their entire life span, which are embedded into dynamic niche microenvironments to sustain their self-renewal, and continuously coordinated with developmental programs and environmental conditions.
We are interested in understanding how plant hormones interact to control the shoot stem cell niche and stem cell behavior. To address this question, we will focus on four related topics: a) define the spatial organization and functions of hormones metabolism in the shoot stem cell niche; b) elucidate the function of MONOPTEROS, a key transcription factor in regulating hormone cross-talk in the stem cell niche; c) probe the mechanisms of core regulatory machinery control in plant stem cells; d) address how stem cell regulatory machinery adapted to nature variation.
As a long-term goal, we aim to understand how individual components of hormone signaling, cell cycle progression and the core regulatory machinery are integrated to control stem cell maintenance and differentiation in the shoot apical meristem.
1.Zhong P, Li J, Luo L, Zhao Z*, Tian Z*. Top1α regulates FLOWERING LOCUS C expression by coupling histone modification and transcription machinery. Development. doi: 10.1242/dev.167841. 2019.
2.Luo L, Zeng J, Wu H, Tian Z*, Zhao Z*. A Molecular Framework for Auxin-Controlled Homeostasis of Shoot Stem Cells in Arabidopsis. Mol Plant. 11(7), 899-913, 2018.
3.Qu X, Zhao Z* and Tian Z*.ERECTA regulates cell elongation by activating auxin biosynthesis in Arabidopsis thaliana. Front. Plant Sci. doi: 10.3389/fpls.2017.01688, 2017.
4.Zeng J, Dong Z, Wu H, Tian Z, Zhao Z*.Redox regulation of plant stem cell fate. EMBO J. 36, 2844-2855, 2017.
5.Zhao Z, Andersen SU, Ljung K, Dolezal K, Miotk A, Schultheiss SJ and Lohmann JU. Hormonal control of the shoot stem cell niche. Nature, 465: 1089-1092, 2010.
6.Feng X*, Zhao Z*, Tian Z*, Xu S, Luo Y, Cai Z, Wang Y, Yang J, Wang Z, Weng L, Chen J, Zheng L, Guo X, Luo J, Sato S, Tabata S, Ma W, Cao X, Hu X, Sun C, Luo D. Control of petal shape and floral zygomorphy in Lotus japonicus. Proc Natl Acad Sci U S A. 103(13): 4970-4975, 2006.
7.Zhao Z, Yu Y, Meyer D, Wu C and Shen WH. Prevention of early floweringby expression of FLOWERING LOCUS C requires methylation of histone H3 K36, Nature Cell Biology, 7(12): 1256-60, 2005.

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