Name:Chengdong Huang
Address:University of Science & Technology of China, Hefei City, Anhui
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2017–presentProfessor, University of Science and Technology of China (USTC)
2017Associate Scientist, St Jude Children’s Research Hospital, Department of Structural Biology
2015–2017Postdoctoral Fellow, University of Minnesota, Department of Biochemistry, Molecular Biology, and Biophysics
2012–2015Postdoctoral Fellow, Rutgers University, Department of Chemistry and Chemical Biology
2010–2012Postdoctoral Fellow, Stony Brook University, Department of Biochemistry and Cell Biology
2004–2010Ph.D., Auburn University, Department of Chemistry and Biochemistry
2001–2004M.S., Dalian Institute of Chemical Physics, Chinese Academy of Sciences
1997–2001B.S. Dalian University of Technology
Our current work primarily focuses on determination of the structural and dynamic basis for the function and assembly of large protein machineries.
1.Huang, Chengdong; Kalodimos, Charalampos, G. Structures of Large Protein Complexes by NMR. Annu. Rev. Biophys. (2017) 46,317-336.
2.Huang, Chengdong; Rossi, Paolo; Saio, Tomohide; Kalodimos, Charalampos, G. Structural basis for the antifolding activity of a molecular chaperone. Nature. (2016) 537, 202-206.
3.Rath, Poonam; Huang, Chengdong; Wang, Tao; Wang, Tianzhi; Li, Huilin; Prados-Rosales, Rafael; Elemento, Olivier; Casadevall, Arturo; Nathan, Carl F. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA. (2013) 110(49), E4790-4797.
4.Huang, Chengdong*; Li, Guangtao*; Lennarz, William J.Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission. (*Equal contribution) Proc. Natl. Acad. Sci. USA (2012) 109(25), 9792-9297.
5.Li, Guangtao*; Huang, Chengdong*, Zhao, Gang; Lennarz, William J. Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97. (*Equal contribution) Proc. Natl. Acad. Sci. USA (2012), 109(10), 3737-3741.
6.Huang, Chengdong; Bhaskaran, Rajagopalan; Mohanty, Smita. Eukaryotic N-glycosylation Occurs Via membrane-anchored C-terminal domain of Stt3p subunit of oligosaccharyl transferase. J. Biol. Chem. (2012) 287(39), 32450-32458.
7.Huang, Chengdong; Mohanty, Smita. Challenging the Limit: NMR Assignment of a 31 kDa Monomeric Helical Membrane Protein. J. Am. Chem. Soc. (2010), 132, 3662–3663.
8.Huang, Chengdong; Mohanty, Smita, Bannerjee, Monimoy. A novel method of production and biophysical characterization of C-terminal domain of Stt3p, the catalyzing subunit of yeast Oligosaccharyl Transferase. Biochemistry (2010), 49, 1115–1126.

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