Name: Dong Long (龙冬)
Born:  1982, Wuhan, Hubei
Address:School of Life Sciences & Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, 230027 Hefei, P. R. China
B.Sc. (2005)Wuhan University, Wuhan, Hubei, China
Ph.D. (2010)National University of Singapore, Singapore                        
2015-presentProfessor, University of Science and Technology of China
2012-2015Postdoctoral Fellow, University of Toronto, Toronto, Canada
2010-2012Postdoctoral Fellow, Florida State University & National High Magnetic Field Laboratory, Tallahasse FL, USA
1)Investigation of the structures and dynamical properties of functionally important proteins and other macromolecules using NMR spectroscopy;
2)Computational modeling/simulation of the structure and dynamics of macromolecular systems;
3)Development of NMR and computational methodology for structural and dynamics studies of biomacromolecules.
1)H. Wang, S. Wang, C. Li, H. Li, Y. Mao, W. Liu, C. Xu*, D. Long* (2017) Probing transient release of membrane-sequestered tyrosine-based signaling motif by solution NMR spectroscopy. J. Phys. Chem. Lett.8:3765-3769
2)Y. Mao, H. Yao, H. Wang, P. Cheng, D. Long* (2016) Microsecond timescale dynamics of GDP-bound Ras underlies the formation of novel inhibitor-binding pockets. Angew. Chem. Int. Ed.55:15629-15632
3)D. Long *, F. Delaglio, A. Sekhar, L. E. Kay * (2015) Probing invisible, excited protein states by non-uniformly sampled pseudo-4D CEST spectroscopy.Angew. Chem. Int. Ed. Engl. 54:10507-10511.
4)D. Long, A. Sekhar, L. E. Kay (2014) Triple resonance-based 13Ca and 13Cb CEST experiments for studies of ms timescale dynamics in proteins.J. Biomol. NMR 60:203-208.
5)D. Long, G. Bouvignies, L. E. Kay (2014) Measuring hydrogen exchange rates in invisible protein excited states. Proc. Natl. Acad. Sci. U.S.A. 111:8820-8825 (Recommended by Faculty of 1000).
6)D. Long, C. B. Marshall, G. Bouvignies, M. T. Mazhab-Jafari, M. J. Smith, M. Ikura, L. E. Kay. (2013) A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues. Angew. Chem. Int. Ed. Engl. 52:10771-10774 (Recommended by Faculty of 1000).
7)H. Sun, D. Long, R. Brüschweiler, V. Tugarinov. (2013) Carbon relaxation in 13Cα-Hα and 13Cα-Dα spin pairs as a probe of backbone dynamics in proteins. J. Phys. Chem. B 117:1308-1320
8)D. Long, R. Brüschweiler. (2013) Directional selection precedes conformational selection in ubiquitin-UIM binding.Angew. Chem. Int. Ed. Engl. 52: 3709-3711.
9)D. Long, R. Brüschweiler. (2012) Structural and entropic allosteric signal transduction strength via correlated motions. J. Phys. Chem. Lett. 3:1722-1726.
10)D. Long, R. Brüschweiler. (2011) Atomistic kinetic model for population shift and allostery in biomolecules.J. Am. Chem. Soc.  133:18999-19005.
11) D. Long, D.W. Li, K. Walter, C. Griesinger, R. Brüschweiler. (2011) Toward a predictive understanding of slow methyl group dynamics in proteins.Biophys. J. 101:910-915.
12)D. Long, R. Brüschweiler. (2011) In silico elucidation of the recognition dynamics of ubiquitin. PLoS Comput. Biol.  7: e1002035.

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