Name:Yunyu Shi (施蕴渝)
Address:School of Life Science,

University of Science and Technology of China,

Hefei, Anhui 230027, P. R. China
Tel:+86-551-63607464
E-mail:yyshi@ustc.edu.cn
Homepage:http://bionmr.ustc.edu.cn/
EDUCATION AND RESEARCH EXPERIENCE
1960-1965Biophysics, Department of Physics, University of Science and Technology of China (USTC).
1965-1970Assistant researcher, Chinese traditional medicine institute, Beijing.
1970-Assistant professor, Lecturer, Associate professor, Professor USTC.
1979-1981Visiting scholar, Department of Chemistry of Roma University and CNRS Lab. of Structural Chemistry, Italy.
1985&1990Visiting Scholar, Department of Chemistry, University of Groningen, Netherlands.
1994Visiting Scholar, CNRS Lab of Structural Biology, Gif-Yvette, France.
1996Visiting Scholar, CNRS Lab of Theoretical Chemistry, University of NANCY, France.
1997Member of the Chinese Academy of Sciences (CAS).
2003Fellow of TWAS (the academy of sciences for the developing world).
RESEARCH INTERESTS
Our laboratory is interested in epigenetic regulation of gene expression, especially histone modifications, chromatin remodeling, histone chaperone, and ncRNA regulation. We are also interested in noncoding RNA interaction with Protein. We use structural biology methods to study structure, dynamics, and function of protein, RNA, and their interactions in epigenetic regulation process.
REPRESENTATIVE PUBLICATIONS (*: corresponding author)
1.Liu, Y; Xu, L; Xie, C; Hong, J; Li, F; Ruan, K; Chen, J; Wu*, J; & Shi*,Y. Structural Insights into ceNAP1 Chaperoning activity toward ceH2A-H2B, Structure, 2019, 27, 1–13.
2.Chen, J;  Wang, Z; Guo, X; Li, Fu; Wei, Q;  Chen, X; Gong, D; Xu, Y; Chen, W; Liu, Y; Kang* J & Shi* Y, TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells, Nature Communications, 2019, 10(1):4273.
3.Yang, Y; Xu, Z; He, C; Zhang. B; Shi*, Y; Li*, F; Structural insights into the recognition of γ-globin gene promoter by BCL11A. Cell Research, 2019, 29,960–963.
4.Liu, X; Shen, S; Wu, P;  Li, F;  Liu, X; Wang, C; Gong, Q; Wu, J; Yao, X; Zhang*, H, Shi* Y. Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. Nucleic Acids Res. 2019; 47(14):7648-7665.
5.Bao, X; Liu, H; Liu, X; Ruan, K; Zhang, Y;  Zhang, Z;  Hu, Q; Liu, Y; Akram, S; Zhang, J; Gong, Q; Wang, W; Yuan, X; Li, J; Zhao, L; Dou, Z; Tian, R; Yao*, X; Wu*, J; Shi*, Y. Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation J Mol Cell Biol. 2018, 10(1):18-32.

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