Name:Cong-Zhao ZHOU (周丛照)
Address:School of Life Sciences

University of Science & Technology of China (USTC)

230027 Hefei, China
Tel:86-551-63600406, 63600407
E-mail:zcz@ustc.edu.cn
Homepage:http://czlab.ustc.edu.cn
EDUCATION
1987 – 1992Department of Biology, USTC, Undergraduate Student
1993 – 1995Department of Biology, USTC, Graduate Student
1997 – 2000Department of Biology, USTC and Université Paris-Sud, Ph.D student
PROFESSIONAL EXPERIENCE
2000 – 2003Postdoc, CNRS & Université Paris-Sud
2004 –Professor in Biochemistry, School of Life Sciences, USTC
2009 – 2014Deputy Dean, School of Life Sciences, USTC
2014 – 2019Dean, Office of Undergraduate Education, USTC
2019 –Provost, USTC
RESEARCH INTERESTS
1.Structural insights into the transcriptional regulation of concerted carbon and nitrogen metabolism in cyanobacteria.
2.Structure, assembly mechanism, molecular ecology and putative applications of freshwater cyanophages.
SELECTED PUBLICATIONS (out of ~120)
*corresponding author, #contributed equally
1.Jin H#, Jiang YL#, Yang F, Zhang JT, Li WF, Zhou K, Ju J, Chen Y*, Zhou CZ*. Capsid structure of a freshwater cyanophage Siphoviridae Mic1. Structure. 27(10):1508-1516.
2.Zhang CC, Zhou CZ, Burnap RL, Peng L. Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria. Trends in Plant Science. 2018; 23(12):1116-1130.
3.Yang HB#, Hou WT#, Cheng MT#, Jiang YL*, Chen Y*, Zhou CZ*. Structure of a MacAB-like efflux pump from Streptococcus pneumoniae. Nature Comm. 2018; 9(1):196.
4.Jiang YL#, Wang XP#, Sun H#, Han SJ, Li WF, Cui N, Li GM, Zhang JY, Cheng W, Cao DD, Zhang ZY, Zhang CC*, Chen Y*, Zhou CZ*. Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proc Natl Acad Sci USA. 2018; 115(2):403-408.
5.Jiang YL#, Jin H#, Yang HB, Zhao RL, Wang SL, Chen Y*, Zhou CZ*. Defining the enzymatic pathway for polymorphic O-glycosylation of the pneumococcal serine-rich repeat protein PsrP. J Biol Chem. 2017; 292(15):6213-6224.
6.Xie J, Cai K, Hu HX, Jiang YL, Yang F, Hu PF, Cao DD, Li WF, Chen Y*, Zhou CZ*. Structural analysis of the catalytic mechanism and substrate specificity of Anabaena alkaline invertase InvA reveals a novel glucosidase. J Biol Chem. 2016; 291(49):25667-77.
7.Yu LY#, Cheng W#, Zhou K#, Li WF, Yu HM, Gao X, Shen X, Wu Q, Chen Y*, Zhou CZ*. Structures of an all-α protein running along the DNA major groove. Nucl Acids Res. 2016; 44(8):3936-45.
8.Jia N, Liu N, Cheng W, Jiang YL, Sun H, Chen LL, Peng J, Zhang Y, Ding YH, Zhang ZH, Wang X, Cai G, Wang J, Dong MQ, Zhang Z, Wu H, Wang HW*, Chen Y*, Zhou CZ*. Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO Reports. 2016; 17(2): 235-48.
9.Shi WW#, Jiang YL#, Zhu F, Yang YH, Shao QY, Yang HB, Ren YM, Wu H*, Chen Y*, Zhou CZ*. Structure of a novel O-GlcNAc transferase GtfA reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins. J Biol Chem. 2014; 289(30):20898-20907.
10.Yang YH#, Jiang YL#, Zhang J, Wang L, Bai XH, Zhang SJ, Ren YM, Li N, Zhang YH, Zhang Z, Gong Q, MEi Y, Xue T, Zhang JR, Chen Y*, Zhou CZ*. Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells. PLoS Pathogens. 2014; 10(6): e1004169.
11.Dai YN, Chi CB, Zhou K, Cheng W, Jiang YL, Ren YM, Ruan K, Chen Y, Zhou CZ*. Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase. J Biol Chem. 2013; 288(32):22985-92.
12.Zhang CC, Zhou CZ. ATPase as a switch in P(II) signal transduction. Proc Natl Acad Sci USA. 2013;110(32):12863-4.
13.Guo PC, Ma JD, Jiang YL, Wang SJ, Bao ZZ, Yu XJ, Chen Y, Zhou CZ*. Structure of yeast sulfhydryl oxidase Erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space. J Biol Chem. 2012; 287(42):34961-9.
14.Cheng W#, Wang L#, Jiang YL, Bai XH, Chu J, Li Q, Yu G, Liang QL, Zhou CZ* and Chen Y*. Structural insights into the substrate specificity of Streptococcus pneumoniae β(1,3) galactosidase BgaC. J Biol Chem. 2012; 287(27):22910-8.
15.Lian FM, Yu J, Ma XX, Yu XJ, Chen Y and Zhou CZ*. Biochemical and structural insights into the catalytic cycle of the yeast peroxiredoxin Ahp1. J Biol Chem. 2012; 287(21):17077-87.
16.He YX#, Zhang NN#, Li WF, Jia N, Chen BY, Zhou K, Zhang J, Chen Y and Zhou CZ*. N-terminal domain of Bombyx mori fibroin mediates assembly of the silk in response to the pH decrease. J Mol Biol. 2012; 418(3-4):197-207.
17.Jiang YL#, Zhang JW#, Yu WL, Cheng W, Zhang CC, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ* and Chen Y*. Structural and enzymatic characterization of a Streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH. J Biol Chem. 2011; 286(41):35906-14.
18.Du Y#, Shi WW#, He YX, Yang YH, Zhou CZ* and Chen Y*. Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC. Biochem J. 2011; 436: 283-9.
19.Ma XX, Guo PC, Shi WW, Luo M, Tan XF, Chen Y and Zhou CZ*. Structural plasticity of the thioredoxin recognition site of yeast methionine-S-sulfoxide reductase Mxr1. J Biol Chem. 2011, 286(15):13430-7.
20.Zhang X, Teng YB, Liu JP, He YX, Zhou K, Chen Y and Zhou CZ*. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1. Biochem J. 2010; 432(3):445-50.
21.Zhao MX#, Jiang YL#, Xu BY, Chen Y, Zhang CC and Zhou CZ*. Crystal structure of cyanobacterial signal transduction protein PII in complex with PipX. J Mol Biol. 2010; 402:552-559.
22.Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC* and Zhou CZ*. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc Natl Acad Sci USA. 2010; 107(28) 12487-92.
23.Luo M, Jiang YL, Ma XX, Tang YJ, He YX, Yu J, Zhang RG, Chen Y, and Zhou CZ*. Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6. J Mol Biol. 2010; 398(4):614-22.
24.He YX#, Huang L#, Xue Y#, Fei X, Teng YB, Rubin-Pitel S, Zhao H* and Zhou CZ*. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2, 4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J Biol Chem. 2010; 285(7):4603-11.
25.Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ*. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family. EMBO Reports. 2009; 10(12):1320-6.

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