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Photoresponsive spherical nucleic acid: spatiotemporal control of the assembly circuit and intracellular microRNA release
Chemical Communications 54(1):106-109 Jan 2018

Zhou, Xiang; Li, Hui; He, Miao; Yin, Xue; Yao, Dongbao; Xiao, Shiyan; Liang, Haojun

Herein, we designed and prepared a photoresponsive spherical nucleic acid (SNA) conjugate by inserting a photocleavable linker into the recognition sequence of SNA which can block the reactivity of the system temporally until specific UV light (∼365 nm) is introduced. The photoresponsive SNA realizes temporal regulation of a self-assembly reaction circuit and spatial selectivity of microRNA release in a cell population, respectively.

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