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Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes
2018-04-26
Angew Chem Int Ed Engl. 57(2):555-559 Jan 2018

Jiang, Bing; Zhao, Meng; Li, Shu-Sen; Xu, Yun-He; Loh, Teck-Peng

Abstract:
A RhIII‐catalyzed intramolecular oxidative cross‐coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo‐ and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3‐conjugated diene structure.

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