Home    News Center    Research Progress
Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes
Angew Chem Int Ed Engl. 57(2):555-559 Jan 2018

Jiang, Bing; Zhao, Meng; Li, Shu-Sen; Xu, Yun-He; Loh, Teck-Peng

A RhIII‐catalyzed intramolecular oxidative cross‐coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo‐ and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3‐conjugated diene structure.

Last updated: Sep. 2018   |  Copyright © Hefei National Laboratory for Physical Sciences at the Microscale  |  Top  |  Site Map