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Solvent-free iodine-promoted synthesis of 3,2 '-pyrrolinyl spirooxindoles from alkylidene oxindoles and enamino esters under ball-milling conditions
Chemical Communications 53(29):12477-12480 Nov 2017

Xu, Hui; Liu, Hong-Wei; Lin, Hao-Sheng; Wang, Guan-Wu

A novel solvent-free iodine-promoted cyclization of alkylidene oxindoles with enamino esters via C–C/C–N bond formation has been demonstrated under ball-milling conditions. This protocol provides efficient and green access to a variety of 3,2′-pyrrolinyl spirooxindoles with remarkable functional group tolerance, good yields and excellent diastereoselectivities.

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