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ZHU Shu, Professor,Young Thousand Talents Program Bio-X Interdisciplinary Sciences
Name:  ZHU Shu(朱书)
Address:   School of Life Science,University of Science and Technology of China (USTC) 443 Huangshang Road, Hefei City, Anhui, 230027, P. R. China
Tel: +86-551-63600620
Fax: None
E-mail:  shuzhu@ustc.edu.cn
 
EDUCATION AND RESEARCH EXPERIENCE
2002-2006 B.Sc. in Biotechnology, The University of Science and Technology of China, Hefei, China
2006-2012 PhD in Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China
2012-2014 Postdoctoral Associate, Yale School of medicine, Dr. Richard Flavell Lab
2012-2017 Postdoctoral Fellow (Helen Hay Whitney Foundation/HHMI), Yale School of medicine, Dr. Richard Flavell Lab
2017-Pre Professor, School of Life Science, USTC, China
 
REWARDS AND HONORS
2006 Guo Moruo Scholarship
2011 The Chinese Academy of Sciences Dean's Award
2011  Johnson & Johnson Asia Outstanding Graduate Thesis Award in Bio-tech
2012 The Chinese Academy of Sciences Dean's Award
2012 Ray Wu Prize
2012 Excellent 100 Doctoral Dissertation of Chinese Academy of Sciences
2014  Helen-Hay Whitney-HHMI Fellowship
2017 Youth 1000 talent program
 
RESEARCH INTERESTS

My research focuses on the host/pathogen/symbiote interface, paying particular attention to the enteric virus/microbiota/immune system interplay in context of human diseases such as norovirus and rotavirus infection, IBD and colorectal cancer.

I will use genetic approach like CRISPR, different mouse models, and next-generation sequencing to define the mechanisms and pathways that control disease pathogenesis and immunity. Specific directions will be: 1) Study how Nod-like receptors recognize pathogens and danger signals in intestine; 2) Study how T cells maintain intestinal homeostasis and how to modulate T cell responses to alleviate inflammatory diseases and cancer; 3) Study how enteric virus and gut microbiota affect immune system and related diseases.

 
REPRESENTATIVE PUBLICATIONS
Innate immune recognition/Infection and Inflammation
1) Zhu S*, Ding S*, Wang P, Wang G, Lei X, Palm N, Pan W, Zheng Y, Feng N, Lu J, Shan L, Abraham C, Fikrig E, Greenberg H, Flavell R. Nlrp9b recognizes and restricts rotavirus infection in intestinal epithelial cells. 2017. Nature. doi:10.1038/nature22967. (Comment in Nature, doi:10.1038/nature23090, Research highlight in Cell Research, doi: 10.1038/cr.2017.93 *co-first author).
2) Wang P*, Zhu S*, Yang L, Cui S, Pan W, Jackson CelR, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R#, Fikrig E#. 2015. Nlrp6 regulates intestinal antiviral innate immunity. Science. 10.1126/science.aab3145. (Comment in Science Signaling (2015), *co-first author, #co-corresponding author)
3) Zhu S, Li HB, Flavell RA. 2014. Resemble and Inhibit: when RLR meets TGF-b. Molecular Cell. Dec 18;56(6):719-20. doi:10.1016/j.molcel.2014.12.010.
4) Zhu S, Jackson R, Flavell RA. 2014. The lock-washer: a reconciliation of the RIG-I activation models. Cell Research.10.1038/cr.2014.5.
5) Shu Zhu, Geng Wang, Xuqiu Lei, Richard A. Flavell. 2016. Mex3B, a coreceptor to present dsRNA to TLR3. Cell Research. 26(4):391-2. doi: 10.1038/cr.2016.29.
6) Marcel R. de Zoete*, Noah W. Palm*, Shu Zhu*, Richard A. Flavell. 2014. Inflammasomes. Cold Spring Haber Perspectives in Biology. (*co-first author)
7) Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. 2016. The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury. Science. 2016 Nov 11;354(6313):765-768.
8) Yao Y., Y. Wang, F. Chen, Y. Huang, S. Zhu, Q. Leng, H. Wang, Y. Shi, Y. Qian. 2012. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogen. Cell Research. 04/2012.
T cells and cytokine /Autoimmune and immune-oncology
1) Li, H.*, J. Tong*, S. Zhu*, P. Batista, J.Zhao, W. Bailis, Y. Yang, G. Wang, Y. Chen, Y. Kluger, Howard Y. Chang, Zhinan Yin, Richard A. Flavell. 2017. m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway pathway. Nature. In press. (*co-first author)
2) Zhu, S.*, W. Pan*, X. Song, Y. Liu, Y. Tang, H. Wang, W. Liu, Y. Shi, D. He, J.B. Harley, N. Shen and Y. Qian. 2012. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nature Medicine. 18: 1077-1086. DOI 10.1038/nm.2815 (Comment in Nature Reviews Immunology (2012) 12, 474-475; Comment in Nature Medicine (2012) 18, 1009–1010; Evaluated by Faculty of 1000 Biology. *co-first author).
3) Zhu, S., W. Pan, P. Shi, H. Gao, F. Zhao, X. Song, Y. Liu, L. Zhao, X. Li, Y. Shi, and Y. Qian. 2010. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med. 207:2647-2662. (Research highlight in Nature Medicine (2011) 17:52; Research highlight in Nature Immunology (2011) 12:19; Evaluated by Faculty of 1000 Biology).
4) Pan W*, Zhu S*, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y,.. Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley J, Flavell R, Yao Y and Shen N. 2015. MiR-125a targets effector programs to stabilize Treg mediated immune homeostasis and controls autoimmunity. Nature Communication. DOI: 10.1038/ncomms8096. (*co-first author)
5) Pan, W*, S. Zhu*, M. Yuan, H. Cui, L. Wang, X. Luo, J. Li, H. Zhou, Y. Tang, and N. Shen. 2010. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol. 184:6773-6781.(*co-first author; 331 citations)
6) Zhu S*, Pan W, Qian Y*. 2013. MicroRNA in immunity and autoimmunity. J Mol Med. (*co-corresponding author; Invited review)
7) Zhu, S. & Qian, Y. 2012. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clin Sci (Lond) 122, 487-511. (Invited review)
8) Song, X., S. Zhu, P. Shi, Y. Liu, Y. Shi, S.D. Levin, and Y. Qian. 2011. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nature Immunology. 12:1151-8.
9) Shi, P., S. Zhu, Y. Lin, Y. Liu, Z. Chen, Y. Shi, and Y. Qian. 2011. Persistent stimulation with interleukin-17 desensitizes cells through SCFbeta-TrCP-mediated degradation of Act1. Science Signaling. 4:ra73.
10) Song X, Dai D, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N, Qian Y. 2015. Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage. Immunity. doi:10.1016/j.immuni.2015.06.024.
11) Pan W, Zhu S, K Qu, K Meeth, J Cheng, H Ma, Y Liao, X Wen, C Roden, Z Tobiasova, Z Wei, J Zhao, J Liu, J Zheng, B Guo, M Bosenberg, R Flavell, J Lu. 2017. Tet2 sustains the immunosuppressive function of myeloid cells and promotes melanoma growth. Immunity. In press.
12) Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y. 2014. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity. 40 (1), 140-152.
13) Yu H, Borsotti C, Schickel JN, Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA. 2016. A novel humanized mouse model with significant improvement of class- switched, antigen-specific antibody production. Blood. doi: 10.1182/blood-2016-04-709584.
14) Cheng J, Roden CA, Pan W, Zhu S, Baccei A, Pan X, Jiang T, Kluger Y, Weissman SM, Guo S, Flavell RA, Ding Y, Lu J. 2016. A Molecular Chipper Technology for CRISPR sgRNA Library Generation and Functional Mapping of Noncoding Regions. Nature Communication. 7:11178. doi: 10.1038/ncomms11178.


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