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LONG Dong, Professor, Young Thousand Talents Program Structure and Function of Biomacromolecules
Name:  Dong Long (龙冬)
Born:   1982, Wuhan, Hubei
Address: School of Life Sciences & Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, 230027 Hefei, P. R. China
Email:  dlong@ustc.edu.cn
B.Sc. (2005) Wuhan University, Wuhan, Hubei, China
Ph.D. (2010) National University of Singapore, Singapore
2015-present Professor, University of Science and Technology of China
2012-2015 Postdoctoral Fellow, University of Toronto, Toronto, Canada
2010-2012 Postdoctoral Fellow, Florida State University & National High Magnetic Field Laboratory, Tallahasse FL, USA
1) Investigation of the structures and dynamical properties of functionally important proteins and other macromolecules using NMR spectroscopy;
2) Computational modeling/simulation of the structure and dynamics of macromolecular systems;
3) Development of NMR and computational methodology for structural and dynamics studies of biomacromolecules.
1) H. Wang, S. Wang, C. Li, H. Li, Y. Mao, W. Liu, C. Xu*, D. Long* (2017) Probing transient release of membrane-sequestered tyrosine-based signaling motif by solution NMR spectroscopy. J. Phys. Chem. Lett. 8:3765-3769
2) Y. Mao, H. Yao, H. Wang, P. Cheng, D. Long* (2016) Microsecond timescale dynamics of GDP-bound Ras underlies the formation of novel inhibitor-binding pockets. Angew. Chem. Int. Ed. 55:15629-15632
3) D. Long *, F. Delaglio, A. Sekhar, L. E. Kay * (2015) Probing invisible, excited protein states by non-uniformly sampled pseudo-4D CEST spectroscopy. Angew. Chem. Int. Ed. Engl. 54:10507-10511.
4) D. Long, A. Sekhar, L. E. Kay (2014) Triple resonance-based 13Ca and 13Cb CEST experiments for studies of ms timescale dynamics in proteins. J. Biomol. NMR 60:203-208.
5) D. Long, G. Bouvignies, L. E. Kay (2014) Measuring hydrogen exchange rates in invisible protein excited states. Proc. Natl. Acad. Sci. U.S.A. 111:8820-8825 (Recommended by Faculty of 1000).
6) D. Long, C. B. Marshall, G. Bouvignies, M. T. Mazhab-Jafari, M. J. Smith, M. Ikura, L. E. Kay. (2013) A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues. Angew. Chem. Int. Ed. Engl. 52:10771-10774 (Recommended by Faculty of 1000).
7) H. Sun, D. Long, R. Brüschweiler, V. Tugarinov. (2013) Carbon relaxation in 13Cα-Hα and 13Cα-Dα spin pairs as a probe of backbone dynamics in proteins. J. Phys. Chem. B 117:1308-1320
8) D. Long, R. Brüschweiler. (2013) Directional selection precedes conformational selection in ubiquitin-UIM binding. Angew. Chem. Int. Ed. Engl. 52: 3709-3711.
9) D. Long, R. Brüschweiler. (2012) Structural and entropic allosteric signal transduction strength via correlated motions. J. Phys. Chem. Lett. 3:1722-1726.
10) D. Long, R. Brüschweiler. (2011) Atomistic kinetic model for population shift and allostery in biomolecules. J. Am. Chem. Soc.  133:18999-19005.
11)  D. Long, D.W. Li, K. Walter, C. Griesinger, R. Brüschweiler. (2011) Toward a predictive understanding of slow methyl group dynamics in proteins. Biophys. J. 101:910-915.
12) D. Long, R. Brüschweiler. (2011) In silico elucidation of the recognition dynamics of ubiquitin. PLoS Comput. Biol.  7: e1002035.

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