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ZHANG Huafeng, Professor,Young Thousand Talents Program Bio-X Interdisciplinary Sciences
Name:  Huafeng Zhang (张华凤)
Address: School of Life Science, The University of Science and Technology of China, 230026, Hefei, P.R. China
Tel: 86-551-63607131(Lab)
E-mail: hzhang22@ustc.edu.cn
 
EDUCATION AND RESEARCH EXPERIENCE
09/1992-07/1997  B S., Department of Pharmacy, Shenyang PharmaceuticalUniversity
09/1997-12/1999  M.S., Department of Pharmacology, ShenyangPharmaceuticalUniversity  
05/2000-09/2000   Visiting Researcher,University of Tokyo, Japan
10/ 2000-03/2004  Ph.D., University of Tokyo,Japan 
04/2004-08/2005   Postdoc, Center for Cancer Research, NCI-Frederick, NIH 
09/2005-01/2008   Postdoc, Johns Hopkins University School of Medicine
02/2008-11/2010  Research Associate, Johns Hopkins University School of Medicine
02/2011 ~present  Professor, University of Science and Technology of China
 
RESEARCH INTERESTS
The major research interest of Dr. Huafeng Zhang is to decipher molecular basis underlying hypoxia and HIF (Hypoxic-inducible-factor) -mediated tumor development and metastasis, with a goal to harness cancers by targeting HIF-mediated pathways. Apart from mechanistic studies, screening for HIF1-specific inhibitors for cancer therapy is also under way in her lab.
 
REPRESENTATIVE PUBLICATIONS 
1) Huang D, Li T, Wang L, Zhang L, Yan R, Li K, Xing S, Wu G, Hu L, Jia W, Lin S, Dang CV, Song L*, Gao P*, Zhang H*. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition stress. Cell Research. 2016; 26(10): 1112-1130.
2)  Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P and Zhang H* HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation is Critical for Cancer Progression. Cell Reports 2014 Sep 25;8(6):1930-42.
3) Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Wang Y, Gao P*, Tang H*, Zhang H* cMyc-Mediated Activation of Serine Biosynthesis Pathway is Critical for Cancer Progression under Nutrient Deprivation Conditions. Cell Research 2015 Apr;25(4):429-44.
4) Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P*, Zhang H*. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature Communications. 2014 Oct 10;5:5212.
5)  Yuan Y, Wang L, Du W, Ding Z, Zhang J, Han T, An L, Zhang H*, Liang G*. Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multidrug Resistance. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9700-4.
6) Li Z, Zhang H*. Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression. Cell Mol Life Sci. 2015 Oct 23. [Epub ahead of print] PMID:26499846.
7) Huang D, Li C, Zhang H*. Hypoxia and cancer cell metabolism. Acta Biochim Biophys Sin. 2014 Mar;46(3):214-9.
8) Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT Jr, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL*. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 31(14), pp1557-70, 2012.
9) Yoshida T#, Zhang H# Shen J, Semenza GL, Campochiaro P.Digoxin Inhibits Retinal Ischemia-induced HIF-1a Expression and Ocular Neovascularization FASEB J. 24(6):1759-67,2010 (#Equal Contributors).
10) Zhang H, Qian DZ, Tan Y, Lee K,Gao P, Ren YR,Rey S, Hammers H, Chang D,1 Pili R, Dang CV, Liu JO and Semenza GL. Digoxin and Other Cardiac Glycosides Inhibit HIF-1a Synthesis and Block Tumor Growth. PNAS 105(50):19579-86,2008.
11) Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem.283(16):10892-903,2008.
12)  Zhang H., Gao P., Fukuda R., Kumar G., Krishnamachary B., Dang CV., Semenza GL. HIF-1 represses mitochondrial mass and respiration in VHL-null renal cell carcinoma. Cancer Cell 11(5):407-20,2007.
13) Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL.HIF-1 RegulatesCytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells. Cell. 129(1):111-22,2007.

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