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LIU Suling, Professor,Young Thousand Talents Program Bio-X Interdisciplinary Sciences
Name:  Suling Liu (柳素玲)
Address: School of Life Sciences, University of Science and Technology of China, 230027 Hefei, P. R. China
Tel: 86-551-63600773
Fax: 86-551-63600773
E-mail: suling@ustc.edu.cn
 
EDUCATION AND RESEARCH EXPERIENCE
09/1992-06/1997 B.S., University of Science & Technology of China
09/1997-09/2003 Ph.D., The Ohio State University, USA
10/2003-09/2006 Postdoc, University of Michigan, USA
10/2006-09/2010 Research Investigator, University of Michigan, USA
10/2010-10/2012 Assistant Professor, University of Michigan, USA
11/2012-Present Professor, University of Science & Technology of China
 
RESEARCH INTERESTS
1) Identifying the different states of breast stem cells to develop the novel combination therapies targeting different breast cancer stem cells.
2) Studying the effects of microRNAs on breast cancer stem cell self-renewal and differentiation, and develop some miRNA-based therapies with nanotechnology.
3) Studying the tumor microenvironment in regulating breast cancer stem cells.
 
HONORS AND AWARDS
1) USCACA‐NFCR Scholarship Award 2014
2) NSFC award for outstanding young investigator (国家“优秀青年”基金) 2014-2016
3) The Thousand Plan Award for Young Investigator from The Organization Department of the Communist Party of China (CPC) Central committee(中组部青年千人) 2012
4) AACR Susan G. Komen Scholar in Training Award 2010
5) AACR-Merck Scholar-in-Training Award 2006
6) Postdoctoral Fellowship from the Susan G. Komen Breast Cancer Foundation 2005-2008
7) Coca Cola Critical Difference for Women Dissertation Grant 2002-2003
8) Travel Award from Program of Enhancement funds for Graduate Students 2001
 
REPRESENTATIVE PUBLICATIONS
1) J. Ke, Z. Zhao, S. Hong, S. Bai, Z. He, F. Malik, J. Xu, L. Zhou, W. Chen, R. Martin-Trevino, X. Wu, P. Lan, Y. Yi, C. Ginestier, I. Ibarra, L. Shang, S. McDermott, T. Luther, S.G. Clouthier, M.S. Wicha, S. Liu*. Role of MicroRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells. Oncotarget 6(6): 3709-3721, 2015. PMID: 25686829.
2) Z. Zhao, S. Li, E.W. Song, S. Liu*. The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells. Protein & Cell (Online), 2015.
3) L. Deng, L. Shang, S. Bai, J. Chen, X. He, R. Martin-Trevino, S. Chen, X. Li, X. Meng, B. Yu, X. Wang, Y. Liu, S.P. McDermott, A.E. Ariazi, C. Ginestier, I. Ibarra, J. Ke, T. Luther, S.G. Clouthier, L. Xu, G. Shan, E. Song, H. Yao, G.J. Hannon, S.J. Weiss, M.S. Wicha, and S. Liu*. MicroRNA100 Inhibits Self-Renewal of Breast Cancer Stem–like Cells and Breast Tumor Development. Cancer Research 74(22): 6648-6660, 2014. PMID: 25217527
4) S. Sun, S. Liu, S. Duan, L. Zhang, H. Zhou, Y. Hu, X. Zhou, C. Shi, R. Zhou, Z. Zhang. Targeting the c-Met/FZD8 signaling axis eliminates patient-derived cancer stem-like cells in head and neck squamous carcinomas. Cancer Research (In press), 2014.
5) Y. Liu, P. Qian, C. Chen, X. Lu, B. Sun, X. Zhang, L. Wang, X. Gao, H. Li, Z. Chen, J. Tang, W. Zhang, J. Dong, R. Bai, P.E. Lobie, Q. Wu, S. Liu, H. Zhang, F Zhao, M.S. Wicha, T. Zhu, Y. Zhao. Fullernol nanomaterial as a novel class of non-toxic cancer stem cell specific inhibitors. Nat Communication 2014 In press.
6) S. Liu*, Y. Cong, D. Wang, Y. Sun, L. Deng, Y. Liu, R. Martin-Trevino, L. Shang, S.P. McDermott, M.D. Landis, S. Hong, A. Adams, R. D'Angelo, C. Ginestier, E. Charafe-Jauffret, S.G. Clouthier, D. Birnbaum, S.T. Wong, M. Zhan, J.C. Chang, M.S. Wicha. Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Cell: Stem Cell Reports 2 (1): 78-91, 2014. PMC3916760
7) S. Liu*, S.H. Patel, C. Ginestier, I. Ibarra, R. Martin-Trevino, S. Bai, S. McDermott, L. Shang, J. Ke, S.J. Ou, A. Heath, K.J. Zhang, H. Korkaya, S.G. Clouthier, E. Charafe-Jauffret, D. Birnbaum, G.J. Hannon, and M.S. Wicha. MicroRNA93 Modulates Breast Cancer Stem Cells by Regulating their EMT/MET States, Proliferation and Differentiation. PlosGenetics 8(6), 2012. PMID: 22685420.
8) S. Liu*, C. Ginestier, S.J. Ou, S.G. Clouthier, S.H. Shivani, F. Monville, H. Korkaya, A. Heath, J. Dutcher, C. Kleer, Y. Jung, G. Dontu, R. Taichman, M.S. Wicha*. Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks. Cancer Res 71(2); 614–24, 2011. (Cover featured). PMID: 21224357
9) H. Korkaya, S. Liu, M.S. Wicha. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. Journal of Clinical Investigation. 2011 Oct 3;121(10):3804-9.PMID: 21965337
10) S. Liu, M. S. Wicha. Targeting breast cancer stem cells. Journal of Clinical Oncology 28(25): 4006-4012, 2010. PMID: 20498387
11) C. Ginestier, S. Liu, M.E. Diebel, H. Korkaya, M. Luo, J. Dutcher, M. Brown, E. Charafe-Jauffret, D. Birnbaum, J.L. Guan, G. Dontu, M.S. Wicha. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. JCI120(2):485-97, 2010. PMID: 20051626
12) C. Ginestier, S. Liu, M.S. Wicha. Getting to the root of BRCA1-deficient breast cancer. Cell Stem Cell 5 (3): 229-230, 2009. PMID: 19733528
13) S. Liu, C. Ginestier, E. Charafe-Jauffret, H. Foco, C.G. Kleer, S.D. Merajver, G. Dontu, M.S. Wicha. BRCA1 Regulates Human Mammary Stem/Progenitor Cell Fate. PNAS (USA) 105 (5): 1680-1685, 2008. PMID: 18230721
14)  C. Ginestier, M.H. Hur, E. Charafe-Jauffret, F. Monville, J. Dutcher, M. Brown, J. Jacquemier, P. Viens, C.G. Kleer, S. Liu, A. Schott, D. Hayes, D. Birnbaum, M.S. Wicha, D. Dontu. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1: 555-567, 2007. PMID: 18371393
15) S. Liu, G. Dontu, I. Mantle, S. Patel, N. Ahn, K.W. Jackson, P. Suri, and M.S. Wicha. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Research 66: 6063-6071, 2006. PMID: 16778178
 
Book Chapters
1) L. Deng, J. Xu, D. Wang, and S. Liu*. Self-Renewal Pathways in Mammary Stem Cells and Carcinogenesis. Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology, Chapter 6, Page 155-174, 2015.
2)  M. Ouzounova, S. Liu, and M.S. Wicha. Stem Cells in Breast Development and Carcinogenesis: Concepts and Clinical Perspectives. Diseases of the breast, 5th edition, Chapter 2, Page 15-24, 2014.
3) Y. Liu, and S. Liu. Role of Cancer Stem Cell in Mammary Carcinogenesis and Its Clinical Implication. Stem Cells and Cancer Stem Cells Vol 10, 189-197, 2013.
4) Mantle, G. Dontu, S. Liu, and M.S. Wicha. Cancer stem cells: implications for development of more effective therapies. Cancer drug resistance, PART II: Biological Resistance. 2005.

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