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XIONG Wei, Professor, Young Thousand Talents Program Bio-X Interdisciplinary Sciences
Name:  Wei Xiong (熊伟)
Born: Nov.1979, Anhui
Address: School of Life Sciences,
University of Science and Technology of China
443 Huangshan Street, Hefei City, Anhui 230027, P.R.China
Tel: +86 551-6360-1736
E-mail: wxiong@ustc.edu.cn
 
EDUCATION AND RESEARCH EXPERIENCE
 03/2013- present Professor, 青年千人,University of Science and Technology of China
 10/2011-03/2013 Research Fellow, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
 10/2006-10/2011 Postdoctoral Fellow, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
 09/2001-07/2006 Ph.D., School of Life Sciences, Peking University
 09/1997-07/2001 B.S., School of Life Sciences, Peking University
 
RESEARCH INTERESTS
1) Ligand-gated ion channels, especially glycine receptor
2) Cellular and molecular mechanisms of pain modulation and motor function
3) Cellular and molecular mechanisms of neurodegenerative diseases
4) Small molecule drug discovery
 
DESCRIPTION
  Our lab has been studying the neurophysiological function and modulation of ligand-gated ion channels, especially glycine receptor (GlyR) and the related medicine, by systematically applying a variety of advanced experimental techniques at the molecular and cellular level and up to animal behavior, involving pharmacology, biochemistry, medicinal chemistry, molecular modeling and mutagenesis, and in vivo nociceptive models. Our major scientific contributions include: 1) The discovery of the mechanism that cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia; 2) Developing new therapeutic medicine (THC analogs) to relieve pain without producing side effects; 3) The discovery that the presynaptic GlyRs could be targeted by cannabinoid drugs for the treatment of hyperekplexia and other neurological disorders involving GlyR deficiency.
  Based on this framework, we would like to further characterize the neurophysiological function and modulation of GlyR and to design new therapeutics to treat the GlyR deficiency-related neurological disorders. Our study will not only improve our understanding of GlyR in the central nervous system, but also may provide us new medicine to treat the related neurological diseases, such as chronic pain, motor disorder and aging-associated diseases.
 
CURRENT RESEARCH PROJECTS
青年千人计划、青年863、“重大新药创制”科技重大专项、国家自然科学基金面上项目
 
REPRESENTATIVE PUBLICATIONS
1) Wei Xiong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-Lin Zhao, Hong Chen, De-Pei Li, Gregg E. Homanics, John Peever, Kenner C. Rice, Ling-gang Wu, Hui-Lin Pan & Li Zhang. Presynaptic glycine receptors as a therapeutic target in dominant familial startle disease. Nature Neuroscience, 17: 232-239, (2014)
Highlight: Kingwell, K. Neurological disorders: Presynaptic glycine receptors become a startling target. Nature Reviews Drug Discovery, doi: 10.1038/nrd4265 (2014).
2) Wei Xiong, KeJun Chen, Tanxing Cui, Grzegorz Godlewski, Kenner Rice, Yan Xu and Li Zhang. Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nature Chemical Biology, 7: 296-303(2011)
Also see NEWS AND VIEWS: Receptors: Cannabis medicine without a high. MacDonald J Christie & Christopher E Vaughan. Nature Chemical Biology, 7:249-250 (2011)
Research Highlight: Nature Reviews Neuroscience 12: 306 (2011)
Commented and rated as ‘Must Read” by Faculty of 1000 (2011)
3) Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu and Li Zhang. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, 209 (6): 1121-1134 (2012)
4) Wei Xiong, Xiongwu Wu, David M. Lovinger and Li Zhang. A Common Molecular Basis for Exogenous and Endogenous cannabinoid Potentiation of Glycine Receptors. Journal of Neuroscience, 32 (15): 5200-5208 (2012)
5) Zhifeng Zhou, Camilla Karlsson, Tiebing Liang, Wei Xiong, Mitsuru Kimura, Jenica D. Tapocik, Qiaoping Yuan, Estelle Barbier, Austin Feng, Meghan Flanigan, Eric Augier, Mary-Anne Enoch, Colin A. Hodgkinson, Pei-Hong Shen, David M. Lovinger, Howard J. Edenberg, Markus Heilig, and David Goldman. Loss of metabotropic glutamate receptor 2 escalates alcohol consumption.PNAS, 110(42):16963-8 (2013)
6) Wei Xiong, Masako Hosoi, Bon-Nyeo Koo, and Li Zhang. Anandamide Inhibition of 5-HT3A Receptors Varies with Receptor Density and Desensitization. Molecular Pharmacology, 73:314-322 (2008)
7) Wei Xiong*,Bon-Nyeo Koo, Russell Morton and Li Zhang. Psychotropic andnonpsychotropic cannabis derivatives inhibit human 5-HT3A receptors through a receptor desensitization-dependent mechanism. Neuroscience,184: 28-37(2011) *Corresponding Author
8) Wei Xiong, Long-Chuan Yu. Involvement of endogenous cholecystokinin in morphine tolerance in the nucleus accumbens of rats. Behavioural Brain Research,173:116-121 (2006)
9) Wei Xiong, Long-Chuan Yu. Involvements of mu- and kappa- opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats. Neuroscience Letters,399: 167-170 (2006)
10) Wei Xiong,LianGao, AygulSapra, Long-Chuan Yu. Antinociceptive role of galanin in the spinal cord of rats with inflammation, an involvement of opioid systems. Regulatory Peptides, 132: 85-90 (2005)
11) Yan Zhang, Wei Xiong, Xiaojin Lin, Xiang Ma and Long-Chuan Yu. Receptor trafficking induced by μ-opioid-receptor phosphorylation. Neuroscience & Biobehavioral Reviews, 33: 1192-1197 (2009)
12) Cecilia M. Borghese, Wei Xiong, S. Irene Oh, Angel Ho, John Mihic, Li Zhang, David M. Lovinger and Gregg E. Homanics. Mutations M287L and Q266I in the glycine receptor alpha1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but Not the minimal alveolar concentration in Knockin Mice. Anesthesiology,117(4):765-771 (2012)
13) Cecilia M. Borghese,Yuri A. Blednov, Yu Quan, Sangeetha V. Iyer, Wei Xiong, S. John Mihic, Li Zhang, David M. Lovinger, James R. Trudell, Gregg E. Homanics, R. Adron Harris. Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols. Journal of Pharmacology and Experimental Therapeutics, 340: 304-316 (2012)
14) Long-Chuan Yu, Shi-Lian Xu, Wei Xiong, Thomas Lundeberg. The effect of galanin on wide-dynamic range neuron activity in the spinal dorsal horn of rats. Regulatory Peptides, 101: 179-182 (2001)
15) Li Zhang and Wei Xiong. Nonpsychoactive cannabinoid action on 5-HT3 and glycine receptors. endocannabinoids, The Receptors Volume 24, pp. 199-218,Springer (2013)
16) Li Zhang and Wei Xiong. Modulation of the cys-loop ligand-gated ion channels by fatty acid and cannabinoids. Vitamins and Hormones, Vol. 81, Burlington: Academic Press, 2009, pp. 315-335 (2009)

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