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WEN Quan, Professor, Hundred Talents Program Bio-X Interdisciplinary Sciences
Name:Quan Wen (温泉)
Address:School of Life Sciences,University of Science & Technology of China,443 Huangshan Rd, Hefei , Anhui , P.R.China
Email: qwen@ustc.edu.cn
Website: www.wenlab.org
 1997-2001 B.S. in physics, Fudan University
 2001-2007 Ph.D in physics, Stony Brook University and Cold Spring Harbor Laboratory
 2007-2009 Associate, Janelia Farm Research Campus, HHMI
 2009-2013 Postdoc, Department of Physics, Harvard University
 2014- Bairen Professor, USTC
1) Neural basis of sensorimotor behavior and optical neurophysiology
2) Structure-function relationship of neural circuit
3) Connectomics
We are interested in understanding how collective activities in a neural circuit give rise to complex behaviors. To address this question, we strive to precisely describe the behavior of interest, to identify the neural computations that drive such behavior, and to elucidate the underlying biophysical mechanisms by which neurons and synapses implement such computations.

At current stage, we focus on using C. elegans as a model system to study the neural basis of sensorimotor behaviors. This millimeter long, optically translucent roundworm has only 302 neurons, for which the entire wiring diagram or connectome has been mapped out at synaptic resolution. Its genetic tractability also allows physiological access to virtually every neuron using optical methods. These advantages hold the promise of a deep understanding of sensorimotor transformation at both algorithmic and mechanistic levels.

1) Luo L*, Wen Q*, Ren J*, Hendricks M*, Gershow M, Qin Y, Greenwood J, Soucy E, Klein M, Smith H.K, Colon-Ramos D, Samuel ADT, Zhang Y, Dynamic encoding of perception, memory and movement in a C. elegans chemotaxis circuit, Neuron 82, 1115-1128, June 4, 2014. *Co-first author.
2) Wen Q, A statistical theory of dendritic morphology, book chapter in The computing dendrite, from structure to function. Springer Series in Computational Neuroscience, Vol. 11, 2014.
3) Williams D, Bejjani R, Ramirez PM, Coakley S, AeKim S, Lee H, Wen Q, Samuel ADT, Lu H, Hilliard M and Hammarlund M, Rapid and permanent neuronal inactivation in vivo via subcellular generation of reactive oxygen with the use of killerRed, Cell Reports 2013;5:553-563.
4) Wen Q*, Po M, Hulme E, Chen S, Liu X, Gershow M, Leifer A, Butler V, Fang-Yen C, Schafer W, Whitesides G, Wyart M, Chklovskii DB, Zhen M and Samuel ADT*, Proprioceptive couplings within motor neurons drive C. elegans forward locomotion Neuron 76, 750–761, November 21, 2012. *Corresponding author. Also see Preview in Neuron 76, 669-670, 2012 and http://f1000.com/prime/717967919, rated as exceptional.
5) Fang-Yen C, Wyart M, Xie J, Kawai R, Kodger T, Chen S, Wen Q and Samuel ADT Biomechanical analysis of gait adaptation in the nematode Caenorhabditis elegans, PNAS, 2010 Nov 23, 107(47) 20323-28.
6) Makara J, Losonczy A, Wen Q and Magee J, Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons, Nature Neuroscience, 2009 Dec;12(12):1485-7.
7) Wen Q, Stepanyants A, Elston G, Grosberg A and Chklovskii DB, Maximizing the connectivity repertoire as a statistical principle governing the dendritic arbor shape, PNAS, 2009 Jul 28;106(30):12536-41. Also see http://f1000.com/1163141#eval623810.
8) Wen Q and Chklovskii DB, A cost-benefit analysis of neuronal morphology, Journal of Neurophysiology, 99, 2320 (May, 2008).
9) Wen Q and Chklovskii DB, Segregation of the brain into gray and white matter: a design minimizing conduction delays PloS Computational Biology, 1(7): e78, Dec 2005. Also see article Highways and byways in the brain. Seed magazine, January 31, 2006.
10) Wen Q and Chklovskii DB, To myelinate or not to myelinate, a cost-benefit analysis Book chapter in Axons: Advances in morphology, physiology, development, computation and pathophysiology (Springer, Norwell MA 02061, U.S.A.).


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