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GONG Weimin, Professor,National Outstanding Youth, Hundred Talents Program Structure and Function of Biomacromolecules
Name: GONG Weimin(龚为民)
Born: Feb. 1968, Anhui
Address: Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China (USTC) Anhui, Hefei ,230022, P. R. China
Tel: 0551-63603819(0)
E-mail: wgong@ustc.edu.cn
Office: Science &Technology Building,  Room 615
   
EDUCATION AND RESEARCH EXPERIENCE
 1995-1996 PhD, School of Life Science, USTC
 1999-2003 Professor, School of Life Science, USTC
 2003-2014 Professor, PI, Institute of Biophysics, Chinese Academy of Sciences
 2014.6-now Professor, PI, Hefei National Laboratory for Physical Sciences at the Microscale, USTC
 
RESEARCH INTERESTS
As a structural biology group, we are interested in structure and function of proteins including:
1) Protein-RNA complexes involved in non-coding RNA generation and regulation.
2) Protein conformational changes triggered by light or odor molecules, based on which novel biosensors are developed.
 
REPRESENTATIVE PUBLICATIONS (*corresponding author)
1) Y Wang, X Han, F Wu, J W.Leung, M G.Lowery, H Do, J Chen, C Shi, C Tian*, L Li*, W Gong*. Structure Analysis of FAAP24 Reveals Single Stranded DNA Binding Activity and Domain Functions in DNA Damage Response. Cell Res. 2013 Oct;23(10):1215-1228. doi: 10.1038/cr.2013.124. Epub 2013 Sep 3.
2) W sun,Y Zhu, Z Wang, Q Zhong, F Gao, J Lou, W Gong*,W Xu*. Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun. 2013 Jul 16;4:2135. doi: 10.1038/ ncomms3135.
3) W Sun, F Gao, H Fan, X Shan, R Sun, L Liu*, W Gong*.The structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteases. Acta Crystallogr D Biol Crystallogr. 2013 May;69(Pt 5):830-7. doi: 10.1107/S0907444913002023. Epub 2013 Apr 11.
4) F Li, P Shi, J Li, F Yang, T Wang, W Zhang, F Gao, W Ding, D Li, J Li, Y Xiong, J Sun, W Gong*, C Tian, J Wang*.A genetically encoded 19F NMR probe for tyrosine phosphorylation. Angew Chem Int Ed Engl. 2013 Apr 2;52(14):3958-62. doi: 10.1002/anie.201300463.
5) X Liu , C Niu , J Ren , J Zhang , X Xie , H Zhu* , W Feng* , W Gong*. The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site. Biochim Biophys Acta(Molecular Basis of Disease), 2013 Feb;1832(2):375-85. doi:10.1016 /j.bbadis. 2012.11.012. Epub 2012 Nov 28.
6) C Niu, J Zhang, F Gao, L Yang, M Jia, H Zhu*, W Gong*. FUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALS. Plos One. 2012;7(10):e47056. Epub 2012 Oct 8.
7) D Zhang, G Liu, J Xue, J Lou, KH Nierhaus, W Gong*,Y Qin*. Common chaperone activity in the G-domain of trGTPase protects L11–L1 interaction on the ribosome. Nucleic Acids Res. 2012 Nov 1;40(21):10851-65. doi: 10.1093/nar/gks833. Epub 2012 Sep 10.
8) R Sun, H Fan, F Gao, Y Lin, L Zhang, W Gong*, L Liu*.Crystal structure of Arabidopsis Deg2 reveals an internal PDZ ligand locking the hexameric resting state. J Biol Chem. 2012 Oct 26;287(44):37564-9.
9) X Liu, J Li, J Dong, C Hu, W Gong*,J Wang*.Genetic incorporation of a metal-chelating amino acid as a probe for protein electron transfer. Angew Chem Int Ed Engl. 2012 Oct 8;51(41):10261-5. Epub 2012 Aug 31.
10) X Wang, J Xue, Z Sun, Y Qin*, W Gong*. Study on the chaperone properties of conserved GTPases. Protein & Cell, 2012, 3(1):44-50.
11) L Sun, M Wang, Z Lv, N Yang, Y Liu, S Bao, W Gong* & R Xu*.Structural insights into protein arginine symmetric dimethylation by PRMT5. PNAS,2011 Dec 20;108(51):20538-43. Epub 2011 Dec 5.
12) SL Fan, MZ Jia, W Gong*,Crystal structure of the C-terminal region of human p97/DAP5. Proteins. 2010 , Aug 1;78(10):2385-90.
13) J Wei, MZ Jia, C Zhang, MZ Wang, F Gao, H Xu*, W Gong*. Crystal structure of the C-terminal domain of the ε subunit of human translation initiation factor eIF2B. Protein & Cell, 2010 Jun;1(6):595-603. doi: 10.1007/s13238-010-0070-6. Epub 2010 Jul 7.
14) R Liu, Ström, A.-L, J Zhai, , J Gal, S Bao, W Gong *, & H Zhu*. Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase. Int. J. Biochem. Cell Biol. 2009 Jun;41(6):1371-80. doi: 10.1016/j.biocel.2008.12.002. Epub 2008 Dec 14.
15) J Cao, H Xu, H Zhao, W Gong* and Debra Dunaway-Mariano*. The Mechanisms of Human Hotdog-fold Thioesterase 2 (hTHEM2) Substrate Recognition and Catalysis Illuminated by a Structure and Function Based Analysis. Biochemistry. 2009 Feb 17;48(6):1293-304. doi: 10.1021/bi801879z.
16) W Gong, B Hao, Z Wei, DJ. Jr Ferguson, T Tallant, JA Krzycki, MK Chan. Structure of the alpha2epsilon2 Ni-dependent CO dehydrogenase component of the Methanosarcina barkeri acetyl-CoA decarbonylase/synthase complex. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9558-63. Epub 2008 Jul 9.

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