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LIAN Zhexiong, Professor,Hundred Talents Program,Changjiang-Professor Structure and Function of Biomacromolecules
Name:  Zhe-Xiong Lian (廉哲雄), M.D., Ph.D.
Address: Institute of Immunology/ School of Life Sciences, University of Science & Technology of China, 443 Huangshan Street, Hefei City, Anhui 230027, P.R.China
Tel: (551) 6360-0317 (Office); 6360-0620 (Lab)
E-mail: zxlian1@ustc.edu.cn
Homepage: http://lianlab.ustc.edu.cn/
 
EDUCATION AND RESEARCH EXPERIENCE
 1984 – 1989 B.S. (Medical), Jilin University, Medical School, China.
 1989 – 1992 Research Fellow, ChangChun Institute of Biological Products, ChangChun City, JiLin, China.
 1992 – 1994 Research Fellow, Kansai Medical University, Osaka, Japan.
 1994 – 1998 Ph.D., Kansai Medical University, Osaka, Japan.
 1998 – 2000 Research Associate, North Shore University Hospital, NY, USA.
 2000 – 2003 Postdoctoral Fellow, University of California at Davis, CA. USA.
 2003 – 2007 SRA IV, University of California at Davis, CA. USA.
 2007 – 2009 Associate Professor, University of California at Davis, CA. USA.
 2009 - Present Professor, University of Science and Technology of China.
 
RESEARCH FIELD OF INTEREST
1) Our research interest mainly focus on autoimmune diseases and basic liver immunology.
2) We are attempting to study molecule and cellular mechanism of autoimmune liver diseases and inflammatory bowel disease.
3) Our final aim is to find a new target of autoimmune diseases for searching a novel medicine.
 
TEN REPRESENTATIVE PUBLICATIONS
1) Yang J-B, Wang Y-H, Yang W, Lu F-T, Ma H-D, Zhao Z-B, Jia Y-J, Tang W, Tsuneyama K, Ridgway WM, Gershwin ME and Lian Z-X*. (2015)Successful Treatment of Murine Autoimmune Cholangitis by Parabiosis. J Autoimmunity. In press.
2) Xie Y-Q, Ma H-D and Lian Z-X*. (2015) Epigenetics and Primary Biliary Cirrhosis: a Comprehensive Review and Implications for Autoimmunity. Clin Rev Allergy Immunol. In press.
3) Lu F-T, Yang W, Wang Y-H, Ma H-D, Tang W,Yang J-B, Liang Li, Aftab A. Ansari and Lian Z-X*. (2015) Thymic B cells promote regulatory T cell development and proliferation. J Autoimmunity. 61:62-72.
4) Wang Y-H, Yang W, Yang J-B, Jia Y-J, Tang W, Gershwin ME, William M. Ridgway and Lian Z-X*. (2015) Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis. J Autoimmunity. 59:26-37.
5) Ma H-D, Wang Y-H, Chang C, Gershwin ME and Lian Z-X*. (2015) The Intestinal Microbiota and Microenvironment in Liver. Autoimmunity Reviews. 14:183-191.
6) Yang W, Yao Y, Yang Y-Q, Lu F-T, Li L, Wang Y-H, Nakajima T, Tsuneyama K, Ridgway WM, Gershwin ME and Lian Z-X*. (2014) Differential Modulation by IL-17A of Cholangitis Versus Colitis in IL-2Ra Deleted Mice. Plos One. 9:e105351.
7) Yao Y, Yang W, Yang Y-Q, Ma H-D, Lu F-T, Li L, Tao Y-Y, Tsuneyama K, Zhang W, Friedman S, Gershwin ME and Lian Z-X*. (2014) Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Rα-/- mice. J Autoimmunity. 51:99-108.
8) Deng Y-R, Yoshida K, Jin Q, Murata M, Yamaguchi T, Tsuneyama K, Moritoki Y, Niu J, Matsuzaki K and Lian Z-X*. (2014) Reversible phosphor-Smad3 signaling between tumor-suppression and fibro-carcinogenesis in chronic hepatitis B infection. Clinical Experimental Immunology. 176:102-111.
9) Deng Y-R, Ma H-D, Tsuneyama K,Yang W, Wang Y-H, Lu F-T, Liu C-H, Liu P, He X-S, Diehl AM, Gershwin ME and Lian Z-X*. (2013) STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. J Autoimmunity. 49:25-34.
10) Tsuda M, Zhang W, Yang GX, Tsuneyama K, Ando Y, Kawata K, Park O, Leung P, Coppel RL, Ansari AA, Ridgway WM, Gao B, Lian Z-X*, Flavell R, He XS and Gershwin ME*. (2013) Deletion of IL-12p35 induces liver fibrosis in dominant negative transforming growth factor β receptor type II mice. Hepatology. 57:806-16.

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