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ZHOU Rongbin, Professor,Hundred Talents Program Structure and Function of Biomacromolecules
Name:  Rongbin Zhou(周荣斌)
Born:   May 19,1980,Hunan,China
Address: School of Life Sciences, University of Science and Technology of China, 230026 Hefei, P. R. China
Tel: 86-551-63600302
Fax: 86-551-63600831
E-mail: zrb1980@ustc.edu.cn
 09/1998-06/2002 B.S., University of Science & Technology of China
 09/2002-06/2007 Ph.D, University of Science & Technology of China
 07/2007-02/2011 Postdoc, University of Lausanne, Switzerland
 03/2011-present Professor, University of Science & Technology of China


Our general interest is to understand how pathogen and danger signal trigger innate immunity and inflammation, and includes the following areas: 


Molecular mechanisms of innate immune recognition and signal transduction:
Analysis of the receptors (pattern recognition receptors, PRRs) the involved in innate immune recognition, including identification of new activators and clarification of the signaling transduction pathways. Our particular interest is to understand the signaling networks that control the activation of “inflmmaosme”.


Basic biology of inflammation:
Inflammation is a fundamental biological response to harmful stimuli, such as pathogens and danger. We are studying the signaling networks that control the initiation, progression and termination of inflammatory responses. We also have interest to understand the links between inflammation and metabolism disorder, inflammation and cancer.



Zhou R, Yazdi A, Menu P,Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011 Jan 13;469(7329):221-5.


Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol. 2010 Feb;11(2):136-40.


Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor for metabolic danger? Science. 2010 Jan 15;327(5963):296-300.


Zhou R, Wei H, Sun R, Zhang J, Tian Z. NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7512-5.


Zhou R, Wei H, Sun R, Tian Z. Recognition of double-stranded RNA by TLR3 induces severe small intestinal injury in mice. J Immunol. 2007 Apr 1;178(7):4548-56.


Zhou R, Wei H, Tian Z. NK3-like NK cells are involved in protective effect of polyinosinic-polycytidylic acid on type 1 diabetes in nonobese diabetic mice. J Immunol. 2007 Feb 15;178(4):2141-7.


Hou X, Zhou R, Wei H, Sun R, Tian Z. NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis. Hepatology. 2009 Mar;49(3):940-9.


Jiang W, Sun R, Zhou R, Wei H, Tian Z. TLR-9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells. J Immunol. 2009 Mar 15;182(6):3768-74.

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