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CHEN Yuxing, Professor Structure and Function of Biomacromolecules

Name:  CHEN Yuxing (陈宇星)
Born:   December 1966, Harbin, P. R. China
Address: School of Life Sciences, University of Science and Technology of China, 230027 Hefei, P. R. China
Tel: 86-551-63602492
E-mail: cyxing@ustc.edu.cn
 
EDUCATION
1980.09 - 1984.07 Department of Appied Physics, Harbin University of Science and Technology, undergraduate student
1987.09 - 1990.05 Department of Applied Physics, Harbin University of Science and Technology, graduate student
2000.09 - 2003.09 Laboratoire d’Enzymologie et Biochimie Structurales (LEBS), CNRS, France, PhD
   
PROFESSIONAL EXPERIENCE
1984.07 - 1987.08 Department of Appied Physics, Harbin University of Science and Technology, Assistant professor, Scientific Research and Teaching
1990.06 - 1998.08 Department of Applied Physics, Harbin University of Science and Technology, Lecturer, Scientific Research and Teaching
1998.08 - 1999.03 Department of Applied Physics, Harbin University of Science and Technology, Associate Professor, Scientific Research and Teaching "Modern Optics"
1999.03 - 2000.03 Institut de Physique Nucleaire (IPN), CNRS, France
2003.09 - 2004.02 Laboratoire d’Enzymologie et Biochimie Structurales (LEBS), CNRS, France, Postdoc
2004.04 - 2007.05 Protein Research Institute, Tongji University, Professor
2007.05 - University of Science and Technology of China, Professor
 
RESEARCH FIELDS
  The structure and function of surface proteins from bacteria: Streptococcus pneumoniae, Mycobacterium tuberculosis and Staphylococcus aureus
 
REPRESENTATIVE PUBLICATIONS
1) Jia N, Liu N, Cheng W, Jiang YL, Sun H, Chen LL, Peng J, Zhang Y, Ding YH, Zhang ZH, Wang X, Cai G, Wang J, Dong MQ, Zhang Z, Wu H, Wang HW, Chen Y*, Zhou CZ*. Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO Reports. accepted.
2) HX, Jiang YL, Zhao MX, Cai K, Liu S, Wen B, Lv P, Zhang Y, Peng J, Zhong H, Yu HM, Ren YM, Zhang Z, Tian C, Wu Q, Oliveberg M, Zhang CC*, Chen Y*, Zhou CZ*. Structural insights into HetR-PatS interaction involved in cyanobacterial pattern formation. Scientific Reports.2015 Nov 18; 5:16470.
3) Li Q#, Cheng W#, Morlot C, Bai XH, Jiang YL, Wang W, Roper DI, Vernet T, Dong YH, Chen Y, Zhou CZ. Full-length structure of the major autolysin LytA. Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1373-81.
4) Bai XH#, Chen HJ#, Jiang YL, Wen Z, Huang Y, Cheng W, Li Q, Qi L, Zhang JR*, Chen Y*, Zhou CZ*. Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis. J Biol Chem. 2014 Aug; 289(34):23403-16.
5) Shi WW#, Jiang YL#, Zhu F, Yang YH, Shao QY, Yang HB, Ren YM, Wu H*, Chen Y*, Zhou CZ*. Structure of a novel O-GlcNAc transferase GtfA reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins. J Biol Chem. 2014 Jul; 289(30):20898-20907.
6) Yang YH#, Jiang YL#, Zhang J, Wang L, Bai XH, Zhang SJ, Ren YM, Li N, Zhang YH, Zhang Z, Gong Q, Mei Y, Xue T, Zhang JR, Chen Y*, Zhou CZ*. Structural insights into SraP-mediated Staphylococcus aureusadhesion to host cells. PLoS Pathogens. 2014 June; 10(6): e1004169.
7) Yu WL, Jiang YL, Pikis A, Cheng W, Bai XH, Ren YM, Thompson J, Zhou CZ*, Chen Y*. Structural insights into the substrate specificity of a 6-phospho-β-glucosidase BglA-2 from Streptococcus pneumoniaeTIGR4. J Biol Chem. 2013 May; 288(21):14949-58.
8) Cheng W#, Wang L#, Jiang YL, Bai XH, Chu J, Li Q, Yu G, Liang QL, Zhou CZ*, Chen Y*. Structural insights into the substrate specificity of Streptococcus pneumoniae β(1,3)-galactosidase BgaC. J Biol Chem.2012 June; 287(27):22910-8.
9) Jiang YL#, Yu WL#, Zhang JW, Frolet C, Di Guilmi AM, Zhou CZ, Vernet T*, Chen Y*. Structural basis for the substrate specificity of a novel β-N-acetyl-hexosaminidase StrH protein from Streptococcus pneumoniaeR6. J Biol Chem. 2011 Dec; 286(50):43004-12.
10) Jiang YL#, Zhang JW#, Yu WL, Cheng W, Zhang CC, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ*, Chen Y*. Structural and enzymatic characterization of the Streptococcal ATP/Diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH. J Biol Chem. 2011 Oct; 286(41):35906-14. 
11) Du Y#, Shi WW#, He YX, Yang YH, Zhou CZ*, Chen Y*. Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC. Biochem J. 2011 Jun; 436(2):283-9.



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