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CAI Gang, Professor Bio-X Interdisciplinary Sciences

Name:  CAI Gang (蔡刚)
Address: No. 443 Huangshan Rd, Hefei, Anhui, China, 230027
School of Life Science, University of Science & Technology of China
Tel: 86-551-63603802
E-mail: gcai@ustc.edu.cn
2012 首届国家基金委“优秀青年科学基金”
2011 教育部新世纪人才支持计划
2010.11-present Professor, University of Science and Technology
2006.03-2010.11 Research Associate, the Scripps Research Institute, USA
2001.09-2006.03 Ph.D. Shanghai Institutes for Biological Sciences
1997.09-2001.07 B.S. Anhui University B.S. in Microbiology, 2001
Cryo electron microscopy (cryo-EM) is a powerful technique to study both the structure and dynamics of macromolecular complexes in their close to native state. I am interested in examining the structures and functional interactions of key macromolecular complexes responsible for regulation of eukaryotic transcription and chromatin structure, aiming at a structural understanding of the molecular mechanism.
1) Wang, X., Chu, H., Lv, M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W*., Cai, G*. Structure of the intact ATM/Tel1 kinase. Nature communications 7, 11655, doi:10.1038/ncomms11655 (2016).
2) Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G*. Redefining the Modular Organization of the Core Mediator Complex. Cell Research 24: 796-808, 2014 (Cover story and highlighted by Prof. Dylan J Taatjes, Mediator redefines itself, Cell Research 24: 775-776, 2014)
3) Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G*. Structural flexibility and functional interaction of Mediator Cdk8 module. Protein Cell 4, 911-920, 2013 (Cover story)
4) Cai, G., Chaban, Y.L., Imasaki, T., Kovacs, J.A., Calero, G., Penczek, P.A., Takagi, Y., and Asturias, F.J.* Interaction of the mediator head module with RNA polymerase II. Structure 20, 899-910, 2012 (Highlighted by Prof. Jianhua Fu, Mutual Remodeling and Conformation Grid: A Mediator Code? Structure 20, 755–757, 2012)
5) Imasaki, T., Calero, G., Cai, G., Tsai, K.L., Yamada, K., Cardelli, F., Erdjument-Bromage, H., Tempst, P., Berger, I., Kornberg, G.L., Asturias, F.J., Kornberg, R.D., Takagi, Y*. Architecture of the Mediator head module. Nature 475, 240-243, 2011
6) Lee., J.H#., Cai, G#., Panigrahi., A.K., Dunham-Ems., S., Nguyen., T.N., Radolf., J.D., Asturias., F.J. & Günzl., A*. A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes. Mol Cell Biol. 30, 5502-13, 2010 (# co-first author)
7) Cai, G., Imasaki, T., Yamada, K., Cardelli, F., Takagi, Y.*, and Asturias, F.J.* Mediator head module structure and functional interactions. Nature Structural & Molecular Biology 17, 273-279, 2010
8) Cai G., Imasaki T., Takagi Y., and Asturias F.J.* Mediator structural conservation and implications for the regulation mechanism. Structure 17, 559-567, 2009 (Cover story, Feature article and highlighted by Conaway, R. C. and Conaway, J. W, Mediator comes out from the shadows, Structure 17, 485–486 2009)

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