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WEN Longping, Professor Bio-X Interdisciplinary Sciences

Name:  Wen Longping (温龙平)
Born:   Dec, 1961, Fujian, P. R. China
Address: School of Life Sciences, University of Science and Technology of China, 230026 Hefei, P. R. China
Tel: 86-551-63600051
Fax: 86-551-63600426
E-mail: lpwen@ustc.edu.cn
 1978-1982 B.S., Xiamen University, China
 1982-1988 Ph.D., University of California, Los Angeles, USA
 1988-1990 Postdoctoral Fellow, Stanford University, USA
 1990-1993 Research Fellow, Institute of Molecular & Cellular Biology, Singapore
 1993-1995  Associate Professor, Xiamen University, China 
 1995-1998 Senior Research Fellow, Stanford University, USA 
 1998-2004 Chief Scientific Officer, BioSun Technologies, USA/China
 2004-Now Professor, University of Science and Technology of China
1) Autophagy modulation by engineered nanomaterials;
2) Targeted and controlled drug delivery using nano-structured carriers;
3) Transdermal drug development and formulations;
4) Other special areas of nanobiology.
1) Nanomaterial-induced autophagy: molecular mechanism, biosafty and applicaltions in cancer diagnosis and therapy. National Basic Research Program of China (2013CB933902; 2012-2017).
2) Modulating the blood retention time and biodistribution for theranostic nanoparticles through circulation-prolonging andsurface-coating peptides obtained through phage display. National Natural Science Foundation of China, Key Project (2015-2019).
1) Chen YP, Shen YY, Guo X, Zhang CS, Yang WJ, Ma ML, Liu S, Zhang MB, Wen LP*. Transdermal protein delivery by a co-administered peptide identified via phage display. Nature Biotechnology 24:455-50 (2006).
2) Zhang YJ, Zheng F, Yang TL, Zhou W, Liu Y, Man N, Zhang L, Jin N, Dou QQ, Zhang Y, Li ZQ & Wen LP*.Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides. Nature Materials. 11, 817–826 (2012).
3) Zhang Q, Yang WJ, Man N, Zheng F, Shen YY, Sun KJ, Li Y and Wen LP*. Autophagy-mediated chemosensitization in cancer cells by fullerene C60 nanocrystal. Autophagy 5(8):1107-17 (2009).
4) Yu L, Lu Y, Man N, Yu SH, Wen LP*. Rare earth oxide nanocrystals induce autophagy in HeLa cells. Small. 5(24):2784-87 (2009).
5) Man N,Yu L, Yu SH and Wen LP* .Rare earth oxide nanocrystals as a new class of autophagy inducers. Autophagy 6,2:310-11(2010).
6) Man N, Chen Y, Zheng F, Zhou W and Wen LP*. Induction of Genuine Autophagy by Cationic Lipids In Mammalian Cells. Autophagy 6,4:449-54 (2010).
7)  Lu Y, Zhang L, Li J, Su YD, Liu Y, Xu YJ, Dong L, Gao HL, Lin J, Man N, Wei PF, Xu WP, Yu SH* and Wen LP*. MnO nanocrystals: A platform for integration of MRI and genuine autophagy induction for chemotherapy. Adv. Funct. Mater., 23: 1534–1546. (2012).
8)  Dong L, Liu Y, Lu Y, Zhang L, Man N, Cao L, Ma K, An D, Lin J, Xu YJ, Xu WP, Wu WB, Yu SH* and Wen LP*. Tuning Magnetic Property and Autophagic Response for Self-Assembled Ni-Co Alloy Nanocrystals. Adv. Funct. Mater. 23: 5930–5940. (2013).
9) Lin J, Huang Z, Wu H, Zhou W, Jin P, Wei P, Zhang Y, Zheng F, Zhang J, Xu J, Hu Y, Wang Y, Li Y, Gu N, Wen LP*.Inhibition of autophagy enhances the anticancer activity of silver nanoparticles. Autophagy. 2;10(11):2006-20. (2014).
10)  Miao YY, Xu J, Shen Y, Chen L, Bian YP, Hu Y, Zhou W, Zheng F, Man N, Shen YY, Zhang YJ, Wang M*, and Wen LP*. Nanoparticle as Signaling Protein Mimic: Robust Structural and Functional Modulation of CaMKII upon Specific Binding to Fullerene C60 Nanocrystals. ACS Nano. 8 (6), pp 6131–6144. (2014).

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