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WANG Guanghui, Professor, Hundred Talents Program Bio-X Interdisciplinary Sciences
Name:  Guanghui Wang (王光辉)
Born:   January 26, 1964, Shanghai, P. R. China
Address: Department of Neurobiology, School of Life Sciences, University of Science and Technology of China, 230027 Hefei, P. R. China
Tel: 86-551-63607058
E-mail: wghui@ustc.edu.cn 
 
EDUCATION AND RESEARCH EXPERIENCE
 Guanghui Wang was born in 1964 in Shanghai, China. From 1981 to 1990 he studied in Shanghai Medical University, Shanghai, China. He received his Bachelor of Medicine degree in 1987 and Master degree in 1990. From 1995 to 2001 he studied in School of Medicine, University of Tokyo, Japan, and received his PhD degree in 2001. Between 2001 and 2003 he was a postdoctoral fellow at School of Medicine, University of Iowa, working on neurodegenerative diseases. He joined School of Life Sciences, USTC as a full professor in September, 2003.
 
RESEARCH INTERESTS
1) The signaling pathway in the pathogenesis of neurodegenerative diseases;
2) The role of modifications of the proteins in neurodegenerative diseases;Professor
3) The molecular mechanisms of the accumulation of mutant proteins in neurodegenerative diseases;
4) The screening of the mediators in neurodegeneration caused by mutant proteins.
 
CURRENT RESEARCH PROJECTS
1) “Post-translational modifications of neurodegenerative disease proteins impacts on disease pathogenesis” supported by Chinese Academy of Sciences (2007-2010)
2) “Effects of phosphorylation of ataxin-3 on its toxicity and property”, supported by Fund of the National Science Foundation of China (NSFC). (2008-2010).
3) “The molecular mechanisms of the disorder of ubiquitin-proteasomal system induced by mutant ataxin-3”, supported by Fund of the National Science Foundation of China (NSFC). (2005-2007).
 
REPRESENTATIVE PUBLICATIONS
1) Fan J, Ren H, Fei E, Jia N, Ying Z, Jiang P, Wu M, Wang G*(2008). Sumoylation is critical for DJ-1 to repress p53 transcriptional activity. FEBS Lett 582:1151-1156
2) Fan J, Ren H, Jia N, Fei E, Zhou T, Jiang P, Wu M, Wang G*(2008). DJ-1 Decreases Bax Expression through Repressing p53 Transcriptional Activity. Journal of Biological Chemistry, 283:4022-4030
3) Zhang T, Jia N, Fei E, Wang P, Liao Z, Ding L, Yan M, Nukina N, Zhou J, Wang G* (2007). Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells. Neuroscience Letters, 423 :118-22
4) Liu C, Fei E, Jia N, Wang H, Tao R, Iwata A, Nukina N, Zhou J, and Wang G* (2007). Assembly of lysine 63 linked ubiquitin-conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis. Journal of Biological Chemistry, 282:14558-14566
5) Wang H, Jia N, Fei E, Wang Z, Liu C, Zhang T, Fan J, Wu M, Chen L, Nukina N, Zhou J, and Wang G* (2007). p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasome. Journal of Neurochemistry, 101:1651-1661
6) Fei E, Jia N, Zhang T, Ma X, Wang H, Liu C, Zhang W, Ding L, Nukina N, Wang G* (2007). Phosphorylation of ataxin-3 by glycogen synthase kinase 3b at serine 256 regulates the aggregation of ataxin-3. Biochem Biophys Res Co 357: 487-492
7) Fei E, Jia N, Yan M, Ying Z, Sun Q, Wang H, Zhang T, Ma X, Ding H, Yao X, Shi Y, Wang G* (2006). SUMO-1 modification increases human SOD1 stability and aggregation. Biochem Biophys Res Co 347 (2): 406-412

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