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YAO Xuebiao, Professor, Changjiang-Professor, National Outstanding Youth, Hundred Talents Program Structure and Function of Biomacromolecules

Name:  Xuebiao Yao(X. Yao, 姚雪彪)
Born:   Sept, 1963, Shanghai, P. R. China
Address: Laboratory of Cellular Dynamics, University of Science and Technology of China, 230026 Hefei, P. R. China
Tel: 86-551-63607141
Fax: 86-551-63606304
E-mail: yaoxb@ustc.edu.cn
 
EDUCATION AND RESEARCH EXPERIENCE
 1980-1984 B.S., Jiangxi College of Chinese Medicine, China
 1991-1995 Ph.D., University of California-Berkeley, USA
 1995-1997 Research Associate, University of California-San Diego, USA
 1997-1999 Assistant Professor, University of Wisconsin-Madison, USA
 2000-2003 Visiting Research Professor, University of California-Berkeley, USA
 2003-2008 Georgia Cancer Coalition Eminent Scholar, USA
 1999- Professor of Cell Biology, University of Science & Technology of China
 2008- Director, Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, China
 
RESEARCH INTERESTS
1) Chromosome segregation and stemness control,
2) Organoids architect and plasticity control,
3) Chemical biology of mitosis and metastasis,
4) Single molecule and super-resolution imaging.
 
CURRENT RESEARCH PROJECTS
1) Centromere Dynamics & Plasticity Control, Natural Science Foundation of China (2017-2012),
2) Chemical biology of mitosis, Chinese Academy of Sciences (2016-2020),
3) Single cell dynamics, Natural Science Foundation of China (2015-2019).
 
REPRESENTATIVE PUBLICATIONS
1) Ding X, Yan F, Yao P, Yang Z, Wan W, Wang X, Liu J, Gao X, Abrieu A, Zhu T, Zhang J, Dou Z, Yao X. (2010). Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin. Cell Res. 20, 1386-1389.
2) Chen Y, Wang D, Guo Z, Zhao J, Wu B, Deng H, Xiang H, Gao F, Yu X, Liao J, Ward T, Xia P, Emenari C. Ding X, Thompson W, Ma K, Zhu J, Aikhionbare F, Dou K, Zhu J, Cheng S, and Yao X. 2011. Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma. Cancer Research 71, 1721-1730.
3) Chen J, Yu F, Gong C, Yao D, Deng H, Wang F, Anderson K, Liu Q, McEwen M, Yao X*, Song E*. 2011. CCL18 from tumor associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 19, 541-555; *correspondence.
4) Tao Y, Jin C, Li X, Qi S, Chu L, Niu L, Yao X*, Teng M*. 2012. The structure of the FANCM-MHF complex reveals physical features for functional assembly. Nature Commun. 3, 782-791.
5) Xia P, Wang Z, Liu X, Wu B, Wang J, Ward T, Zhang L, Ding X, Gibbons G, Shi Y, Yao X. (2012). EB1 acetylation by PCAF ensures accurate kinetochore-microtubule interactions in mitosis. Proc Natl Acad Sci U S A. 109, 16564-9.          
6) Zhao X, Wang D, Liu X, Liu L, Song Z, Zhu T, Adams G, Gao X, Tian R, Huang Y, Chen R, Wang F, Teng M, Ding X, Yao X. (2013) Phosphorylation of the BAR domain of ACAP4 regulates membrane tabulation. Proc Natl Acad Sci U S A. 110, 11023-8.         
7) Yao X, Li D, Pei G. 2013. In focus: Molecular and Cell Biology Research in China. Nat Rev Mol Cell Biol. 14, 600-606.
8) Dou Z, Liu X, Wang W, Zhu T, Wang X, Xu L, Abrieu A, Fu C, Hill DL, Yao X*.2015. Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment. Proc Natl Acad Sci USA.112, E4546-55.
9) Mo F, Zhuang X, Liu X*, Yao P, Qin B, Su Z, Zang J, Wang Z, Zhang J, Niu L, Hill DL, Fang G, Fu C, Yao X*. 2016. Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nature Chem. Biol. 12, 226-232.  *correspondence.


 

 



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