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WEI Haiming, Professor Structure and Function of Biomacromolecules
  Name:  Haiming Wei(魏海明)
Born:   Oct, 1963, Hefei, P. R. China
Address: School of Life Sciences , University of Science and Technology of China, 230026 Hefei, P. R. China
Tel: 86-551-63607379
Fax: 86-551-63606783
E-mail: ustcwhm@ustc.edu.cn
 
EDUCATION AND RESEARCH EXPERIENCE
1993.08-1996.07 M.s., Immunology, Shandong Academy of Medical Sciences,
2000.08-2003.07 Ph. D., Immunology, Shandong University,
1996.07-2001.09 Assistant Professor and Associate Professor of Shandong Cancer Biotherapy Center, Institute of Basic Medical Sciences, Shandong Academy of Medical Sciences
2001.09-2005.12 Associate Professor of School of Life Sciences, USTC
2005.12-2014.12 Professor of School of Life Sciences, USTC
2015.01-present Professor & Vice-Dean of School of Life Sciences, USTC
 
RESEARCH INTERESTS
1) Innate immunity and immune diseases;
2) Tumor immunity and tumor biotherapy;
3) Recognition and differentiation of NK cells;
 
CURRENT RESEARCH PROJECTS
1) Phenotypic and functional characterization of human decidual NK cells at the maternal-fetal interface, 2015.1-2018.12, supported by National Natural Science Foundation of China
2) Microenvironment elements involved in the programmed differentiation and proliferation of human NK cell, 2014.01-2018.12, supported by National Natural Science Foundation of China
3) Antitumor activity of interleukin 12 against lung cancer, 2016.6-2018.12, supported by Chinese Academy of Sciences
 
REPRESENTATIVE PUBLICATIONS
1) Zheng X, Fan X, Fu B, Zheng M, Zhang A, Zhong K, Yan J, Sun R, Tian Z, Wei H. EpCAM inhibition sensitizes chemoresistant leukemia to immune surveillance.Cancer Res. 2016 Oct 3. pii: canres.0842.
2) Zheng X, Cheng M, Fu B, Fan X, Wang Q, Yu X, Sun R, Tian Z, Wei H. Targeting LUNX inhibits non-small cell lung cancer growth and metastasis. Cancer Res. 2015 Mar 15;75(6):1080-90.
3) Lv S, Wang J, Dou S, Yang X, Ni X, Sun R, Tian Z, Wei H. Nanoparticles encapsulating HBV-CpG induce therapeutic immunity against hepatitis B virus infection. Hepatology. 2014 Feb 59(2):385-94.
4) Ni F, Sun R, Fu B, Wang F, Guo C, Tian Z, Wei H. IGF-1 promotes the development and cytotoxic activity of human NK cells. Nat Commun. 2013 Feb 12; 4:1479.
5) Fu B, Li X, Sun R, Tong X, Ling B, Tian Z, Wei H. Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):E231-40.
6) Li F, Wei H, Wei H, Gao Y, Xu L, Yin W, Sun R, Tian Z. Blocking the Natural Killer Cell Inhibitory Receptor NKG2A Increases Activity of Human Natural Killer Cells and Clears Hepatitis B Virus Infection in Mice. Gastroenterology. 2013 Feb;144(2):392-401.
7) Sun C, Fu B, Gao Y, Liao X, Sun R, Tian Z, Wei H. TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. PLoS Pathog. 2012;8(3):e1002594.

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