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TIAN Zhigang, Professor, National Outstanding Youth, Hundred Talents Program Structure and Function of Biomacromolecules
  Name:  Zhigang Tian(田志刚)
Born:   Oct, 1956, Shandong, P. R. China
Address: School of Life Sciences , University of Science and Technology of China, 230026 Hefei, P. R. China
Tel: 86-551-63600845
Fax: 86-551-63606783
E-mail: tzg@ustc.edu.cn
 
EDUCATION AND RESEARCH EXPERIENCE
 03/1978-12/1982 M.D., Shanxi Medical University, China
 03/1983-08/1985 M.S.,Immunol,Shandong Acad Med Sci, China
 03/1986-03/1989 Ph.D., Immunology, Normal Bethune Med Univ, China.
 04/1989-12/2001 Assist/Asso/Full Professor, Shandong Acad Med Sci,
 08/1994-06/1996 Visiting Scientist, NCI, NIH, USA
 02/1999-08/1999 Visiting Professor, Med College Virginia, Richmond
 08/2000-12/2000 Visiting Scientist, NCI, NIH, USA
 01/2001-present Professor, Univ Sci Tech China, China
 01/2002-04/2002 Visiting Scientist, NIAAA, NIH, USA
 05/2002-04/2003 Visiting Professor, Kanazawa Univ Cancer Inst, Japan
 
RESEARCH INTERESTS
1) Innate immunity of liver
2) Regulatory function of NK cells in specific immune response ;
3) Differentiation process of NK cells.
 
CURRENT RESEARCH PROJECTS
  Currently, we are supported through 7 research projects by National Natural Science Foundation of China, Department of Science & Technology of Chinese Government, and Chinese Academy of Sciences.
 
REPRESENTATIVE PUBLICATIONS
1) Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome. Cell. 2015 Jan 15;160(1-2):62-73.
2) Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*, Tian Z*. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice. J Hepatol. 2015 Jan 9. pii: S0168-8278(14)00956-8.
3) Wang J, Li F, Wei H, Lian ZX, Sun R, Tian Z*. Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation. J Exp Med. 2014 Nov 17;211(12):2397-410.
4) Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z*, Zhou R*. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014 Dec;15(12):1126-33.
5) Tian Z. Outflanking HCV. Nat Immunol. 2014 Jan;15(1):6-8.
6) Jiang W, Wang X, Zeng B, Liu L, Tardivel A, Wei H, Han J, MacDonald HR, Tschopp J, Tian Z*, Zhou R*. Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med. 2013 Oct 21;210(11):2465-76.
7) Xu L, Yin W, Sun R, Wei H, Tian Z*. Kupffer cell-derived IL-10 plays a key role in maintaining humoral immune tolerance in hepatitis B virus-persistent mice. Hepatology. 2014 Feb;59(2):443-52.
8) Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z*, Tschopp J, Zhou R*. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013 Jun 27;38(6):1154-63.
9) Peng H, Jiang X, Chen Y, Sojka D, Gao X, Sun R, Wei H, Yokoyama W, Tian Z*. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. J Clin Invest 2013, 123(4):1444-1456.
10) Li F, Wei H, Wei H*, Gao Y, Xu L, Yin W, Sun R, Tian Z*. Blocking the Natural Killer (NK) Cell Inhibitory Receptor NKG2A Increases Activity of Human NK Cells and Clears HBV Infection in Mice.Gastroenterology. 2013, 144:392-401.
11) Xu L, Yin WW, Wei HM, Sun R, Tian Z*. Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant mice. PNAS USA 2013; 110:16993-8.
12) Wang J, Li F, Sun R, Gao X, Wei H, Li L, Tian Z*. Airway bacteria dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages. Nat Commun 2013; 4:2106.
13) Lan PX, Zhang C, Han QJ, Zhang J, Tian ZG*. Reversal of HBV-induced systemic adaptive immunotolerance by recovering hepatocyte-intrinsic immunity. Hepatology 2013, 58:73-85.
14) Wang X, Sun R, Wei H, Tian Z*. HMGB1-TLR4-IL-23-IL-17A axis in drug-induced lethal hepatitis: Interaction of γδ T cells with macrophages. Hepatology. 2013; 57:373-84.
15) Huang M, Sun R, Wei H, Tian Z*. Simultaneous knockdown of multiple ligands of NKG2D high efficiently prevents NK cell-mediated fulminant hepatitis. Hepatology. 2013; 57:277-88.

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