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TIAN Changlin, Professor, Hundred Talents Program Structure and Function of Biomacromolecules

Name: Changlin Tian (田长麟)
Born: WuHan, HuBei
Tel: 86-551-63606872(O)
Email: cltian@ustc.edu.cn
Office: Room 524, School of Life Science, USTC
 1997.09-2003.05 Ph.D. in Molecular Biophysics, Institute of Biophysics, Florida State University, Tallahassee, FL, USA
 1995.09-1997.07 M.S. in Molecular Biology, Department of Biological Science and Technology, Shanghai Jiao Tong University
 1991.09-1995.07 B.S. in Applied Electronic Technology, Department of Information Control
B.S. in Biochemical Engineering, Department of Biological Science and Technology, Shanghai Jiao Tong University, Shanghai, P. R. China
Working Experience and Affiliation
2014.10-Present Director, Division of General Administration,Hefei Science Center,Chinese Academy of Sciences
2009.08-2014.09 Deputy Director, High Magnetic Field Laboratory, Chinese Academic of Science
2006.11-Present Professor of Biochemistry and Molecular Biology, School of Life Science, University of Science and Technology of China, Hefei, Anhui, P. R. China
2003.03-2007.02 Postdoctoral Research Associate, Center for Structural Biology, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA
1998.01-2003.03 Research Assistant, Center for Interdisciplinary of Magnetic Resonance, National High Magnetic Field Laboratory, Tallahassee, FL, USA
2010.04-Present Associate Director of Molecular Biophysics Committee, the Biophysical Society of China
2008.12 Young Faculty Career Award, University of Science and Technology of China Alumni Foundation
2007.12 Young Investigator Award, Huo-Ying-Dong Education Foundation
2006.01-2008.12 Postdoctoral Fellowship Award, American Heart Association (stopped on 03/2006, due to resignation from Vanderbilt University)
Working Experience and Affiliation
2014.04-Present General Secretary of Biological Magnetic Resonance Branch, the Biophysical Society of China
Research Interests
Research interests in Dr. Changlin Tian’s lab is focusing on three parts:

1)Developing biophysical methods to analyze protein-protein interactions and protein dynamic properties in-situ or in native cellular (both prokaryotic and eukaryotic) environments. The methods include nuclear magnetic resonance (NMR), electron spin resonance (ESR), fluorescence and other related spectroscopic methods.

2)Developing chemical synthesis methods for unnatural amino acids and polypeptides.

3)Structure and function studies of ion channels. Using the combinational structural biology methods to illustrate three dimensional structures of ion channels, modulatory subunits and/or native toxins. Using the patch-clamp methods to illustrate physiological behavior of ion channels and their functional variations under different modulatory molecules. 
1) Structure, Dynamics and Physiology studies of Potassium Channel and its Modulation Protein
2) Method Development of Magnetic Resonance (NMR, EPR) and combination studies with other biophysical methods
1) Liu S, Lv P, Li D, Guo X, Zhang B, Yu M, Li D, Xiong Y, Zhang L, Tian C. K(+) preference at the NaK channel entrance revealed by fluorescence lifetime and anisotropy analysis of site-specifically incorporated (7-hydroxycoumarin-4-yl)ethylglycine.Chem Commun (Camb). 2015 Nov 14;51(88):15971-4. doi: 10.1039/c5cc06124e. Epub 2015 Sep.
2) Sun P, Wu F, Wen M, Yang X, Wang C, Li Y, He S, Zhang L, Zhang Y, Tian C. A distinct three-helix centipede toxin SSD609 inhibits I(ks) channels by interacting with the KCNE1 auxiliary subunit.Sci Rep. 2015 Aug 26;5:13399. doi: 10.1038/srep13399. PMID:26307551.
3) Li J, Shi C, Sun D, He Y, Lai C, Lv P, Xiong Y, Zhang L, Wu F, Tian C. The HAB1 PP2C is inhibited by ABA-dependent PYL10 interaction.Sci Rep. 2015Jun5;5:10890.doi: 10.1038/srep10890.
4) Guo. Ange Y, Sun DM, Wang FL, He Y, Liu L, Tian CL. Diaminodiacid Bridges to Improve Folding and Tune the Bioactivity of Disulfide-Rich Peptides. Angew Chem Int Ed Engl. 2015 Jun 1. doi: 10.1002/anie.201500699. [Epub ahead of print].PMID:26031649.
5) Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L, Tian C. Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells. Chem Commun (Camb). 2015 May 11;51(38):8153-6. doi: 10.1039/c5cc01418b. Epub 2015 Apr 15.
6) Q. Liu, C. Shi, L. Yu, L. Zhang, Y. Xiong, C. Tian.General order parameter based correlation analysis of protein backbone motions between experimental NMR relaxation measurements and molecular dynamics simulations. Biochem Biophys Res Commun. 2015 Feb 13;457(3):467-72.
7) D. Li, J. Li, Y. Zhuang, L. Zhang, Y. Xiong, P. Shi, C. Tian. Nano-size uni-lamellar lipodisq improved in situ auto-phosphorylation analysis of E. coli tyrosine kinase using (19)F nuclear magnetic resonance, Protein Cell .  2015 Mar;6(3):229-33.
8) X. Guo, L. Wang, J. Li, Z. Ding, J. Xiao, X. Yin, S. He, P. Shi, L. Dong, G. Li, C. Tian, J. Wang, Y. Cong, Y. Xu. Structural insight into autoinhibition and histone H3-induced activation of DNMT3A. Nature. 2015 Jan 29;517(7536):640-4.
9) L. Yu, W. Wang, S. Ling, S. Liu, L. Xiao, Y. Xin, C. Lai, Y. Xiong, L. Zhang, C. Tian. CW-EPR studies revealed different motional properties and oligomeric states of the integrin beta1a transmembrane domain in detergent micelles or liposomes, Sci Rep . 2015 Jan 19;5:7848.

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