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SHI Qinghua, Professor, National Outstanding Youth, Hundred Talents Program Structure and Function of Biomacromolecules

  Name:  Qinghua Shi(史庆华)
Born:   September 4, 1964, Jiangsu, P. R. China
Address: Hefei National Laboratory for Physical Science at Microscale and School of Life Science, University of Science and Technology of China, 230026 Hefei,CAS Center for Excellence in Molecular Cell Science, P. R. China
Tel: 86-551-63600344/63600442(L)
Labweb: http://mcg.ustc.edu.cn
E-mail: qshi@ustc.edu.cn
 
EDUCATION AND RESEARCH EXPERIENCE
 1985.09—1988.10 Graduate for M.S. degree. Kunming Institute of Zoology, Chinese Academy of Sciences.
 1988.11—1992.09 Research Assistant. Anhui Institute of Occupational Health
 1992.10—1993.10 Guest Scientist. GSF-National Research Center for Environment and Health, Germany.
 1994.09—1998.06 Graduate for Ph.D. degree. GSF-National Research Center for Environment and Health, Germany and, Nanjing Normal University.
 1998.11—2001.12 Postdoctoral fellow. Department of Medical Genetics, University of Calgary, Canada.
 2002.01—2004.12 Research Fellow. Institute of Chemistry and Cell Biology, Department of Cell Biology, Harvard Medical School.
 2004.12—present Principal Investigator and Professor. Hefei National Laboratory for Physical Science at Microscale and, School of Life Science, University of Science and Technology of China
 
RESEARCH INTERESTS
1) Cellular and molecular regulation of mammalian meiosis.
2) Origins and mechanisms of mitotic and meiotic aneuploidy.
3) Molecular basis and mechanisms of human infertility.
 
CURRENT RESEARCH PROJECTS
1) Molecular regulation of human and mammalian meiosis.
2) Molecular mechanisms of oocyte and follicle development.
3) Identification of genetic mutations causing human spermatogenesis and oogenesis failure.
4) Origins and mechanisms of mitotic and meiotic aneuploidy.
 
REPRESENTATIVE PUBLICATIONS
1) Shi QH(史庆华)and King RW: Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 437:1038, 2005.
2) Huang Y, Jiang L, Yi Q, Lv L, Wang Z, Zhao X, Zhong L, Jiang H, Hao Q, Guo Z, Cooke HJ, Fenech M, Shi Q(史庆华)*. Lagging chromosomes entrapped in micronuclei are not 'lost' by cells.Cell Res 22: 932, 2012.
3) Zhang Y, Zhong L, Xu B, Yang Y, Ban R, Zhu J, Cooke HJ, Hao Q, Shi Q(史庆华)*. SpermatogenesisOnline 1.0: a resource for spermatogenesis based on manual literature curation and genome-wide data mining.Nucleic Acids Res 41: D1055-62, 2013.
4) Jiang X, Zhang H, Yin S, Zhang Y, Yang W, Zheng W, Wang L, Wang Z, Bukhari I, Cooke HJ, Iqbal F, Shi Q(史庆华)*. Specific deficiency of Plzf paralog, Zbtb20, in Sertoli cells does not affect spermatogenesis and fertility in mice. Scientific Reports 4:7062, 2014.
5) Zhang Y, Yu Z, Ban R, Zhang H, Iqbal F, Zhao A, Li A, Shi Q(史庆华)*. DeAnnCNV: a tool for online detection and annotation of copy number variations from whole-exome sequencing data. Nucleic Acids Res 2015 doi: 10.1093/nar/gkv556.

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