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NIU Liwen, Professor, National Outstanding Youth Structure and Function of Biomacromolecules

Name:  Liwen NIU(牛立文)
Born:   October, 1962. P. R. China
Address: School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China
Tel: 86-551-63603046
E-mail: lwniu@ustc.edu.cn
 Graduated from Department of Biology USTC in 1982, and received the degree of Master of Science from Institute of Biophysics, Chinese Academy of Sciences (CAS) in 1986.
 Since 1986, Prof. Liwen Niu has had a job as Professor Assistant (1986-1987), Lecturer (1987-1989), Associate Professor (1989-1995) and Professor (1995-now) in University of Science and Technology of China, and as Visiting Associate Professor (1993) and Research Associate (1995-1996), has joined the teamwork headed by Dr. Janet Smith in Purdue University USA.
 Vice-chair of Department of Biology USTC (1994-1997); Associate Dean (1998-2003) and Chief Executive Dean (2003-now), School of Life Sciences USTC; Vice-director (1997-2002) and Director (2002-now), Key Laboratory of Structural Biology, CAS; Standing member (1999-now) and Director of Macromolecular Committee (2004-now), Crystallographic Union of China; Standing Member, Society of Biophysics of China (2001-now).
 Research interests are in the fields of Structural Biology and Structural Genomics, including the studies on structure-function relationships of macromolecular interactions involved in various biological processes, especially in the areas of protein X-ray crystallography, protein engineering and bio-molecular design etc. The crystal structures of some macromolecules have been conducted in the past years.

 Financial support to Prof. Liwen Niu has been mainly provided by several research grants from China National Natural Science Foundation, 973 Plan and 863 Plan of China Ministry of Science and Technology, and Chinese Academy of Sciences.
1) Deqiang Wang, Min Guo, Zhi Liang, Jun Fan, Zhiqiang Zhu, Jianye Zang, Zhongliang Zhu, Xiaowu Li, Maikun Teng, Liwen Niu*, Yuhui Dong, and Peng Liu, Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase nuclease-like fold and two protein-protein interaction sites. J. Biol. Chem., Mar 2005; 10.1074.
2) Q. Liu, Q. Q. Huang, M. K. Teng, C. M. Weeks, C. Jelsch, R. G. Zhang and L. W. Niu*, The Crystal Structure of a Novel, Inactive, Lysine 49 PLA2 from Agkistrodon acutus Venom. J. Biol. Chem., 278, 41400 - 41408, (2003).
3) Lou X, Liu Q, Tu X, Wang J, Teng M, Niu L*, Schuller DJ, Huang Q, Hao Q.J, The atomic resolution crystal structure of atratoxin determined by SAD phasing, J. Biol. Chem., Vol. 279, No. 37, Issue of September 10, 39094–39104, (2004).
4) Zhongliang Zhu, Zhi Liang, Tianyi Zhang, Zhiqiang Zhu, Weihua Xu, Maikun Teng, and Liwen Niu*, Crystal Structures and Amidolytic Activities of Two Glycosylated Snake Venom Serine Proteinases, J. Biol. Chem., Mar 2005; 280: 10524 – 10529.
5) Min Guo, Maikun Teng, Liwen Niu*, Qun Liu, Qingqiu Huang, and Quan Hao, Crystal structure of cysteine-rich secretory protein stecrisp reveals the cysteine-rich domain has a K+-channel inhibitor-like fold. J. Biol. Chem., Dec 2004; 10.1074.

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