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LIU Shiyong, Professor, National Outstanding Youth, Hundred Talents Program Low-dimensional Physics and Chemistry
Name:  Shiyong Liu(S. Y. Liu 刘世勇)
Born:   Oct, 1972, Hubei, P. R. China
Address:  Department of Polymer Science and Engineering, University of Science and Technology of China, 230026 Hefei, P. R. China
Tel: 86-551-63607348
Fax: 86-551-63607348
E-mail: sliu@ustc.edu.cn
Research group: http://staff.ustc.edu.cn/~sliu
 
EDUCATION AND RESEARCH EXPERIENCE
 1989-1993 B.S., Wuhan University
 1993-1996 M.S. Wuhan University
 1996-2000 Ph.D. Fudan University
 2000-2002 Research Fellow, University of Sussex, England
 2002-2003 Research Associate, University of Delaware
 2004-present Professor, University of Science and Technology of China
 
RESEARCH INTERESTS
1) Controlled Synthesis of Polymers with Complex Architectures
2) Chemosensors and Biosensors for Clinical Diagnostics
3) Supramolecular Self-Assembly and Functional Materials
4) Kinetics of Chain Folding, Aggregation, and Assembly
5) Biomaterials, Nanomedicine, Bioimaging
 
REPRESENTATIVE PUBLICATIONS
1) X. R. Wang, J. M. Hu, G. H. Liu, J. Tian, H. J. Wang, M. Gong, S. Y. Liu* "Reversibly Switching Bilayer Permeability and Release Modules of Photochromic Polymersomes Stabilized by Cooperative Noncovalent Interactions", J. Am. Chem. Soc. 2015, 137, 15262-15275.
2) G. H. Liu, G. F. Zhang, J. M. Hu, X. R. Wang, M. Q. Zhu, S. Y. Liu* "Hyperbranched Self-Immolative Polymers (hSIPs) for Programmed Payload Delivery and Ultrasensitive Detection", J. Am. Chem. Soc. 2015, 137, 11645-11655.
3) X. L. Hu, G. H. Liu, Y. Li, X. R. Wang, S. Y. Liu* “Cell-Penetrating Hyperbranched Polyprodrug Amphiphiles for Synergistic Reductive Milieu-Triggered Drug Release and Enhanced Magnetic Resonance Signals” J. Am. Chem. Soc. 2015, 137, 362-368 (JACS Spotlights).
4)  Y. M. Li, G. H. Liu, X. R. Wang, J. M. Hu, S. Y. Liu* "Enzyme-Responsive Polymeric Vesicles for Bacterial Strain-Selective Delivery of Antimicrobial Agents", Angew. Chem. Int. Ed. DOI: 10.1002/anie.201509401 (2015)
5) Y. M. Li, H. S. Yu, Y. F. Qian, J. M. Hu, S. Y. Liu* “Amphiphilic Star Copolymer-Based Bimodal Fluorogenic/Magnetic Resonance Probes for Concomitant Bacteria Detection and Inhibition” Adv. Mater. 2014, 26, 6734-6741.
6) X. R. Wang, J. M. Hu, G. Y. Zhang, S. Y. Liu*“Highly Selective Fluorogenic Multianalyte Biosensors Constructed via Enzyme-Catalyzed Coupling and Aggregation-Induced Emission” J. Am. Chem. Soc.2014, 136, 9890-9893.
7) G. H. Liu, X. R. Wang, J. M. Hu, G. Y. Zhang, S. Y. Liu* “Self-Immolative Polymersomes for High-Efficiency Triggered Release and Programmed Enzymatic Reactions” J. Am. Chem. Soc.2014, 136, 7492-7497.
8) X. R. Wang, G. H. Liu, J. M. Hu, G. Y. Zhang, S. Y. Liu* “Concurrent Block Copolymer Polymersome Stabilization and Bilayer Permeabilization via Stimuli-Regulated ‘Traceless’ Crosslinking” Angew. Chem. Int. Ed. 2014, 53, 3138-3142.
9) X. L. Hu, J. M. Hu*, J. Tian, Z. S. Ge, G. Y. Zhang, K. F. Luo, S. Y. Liu*"Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking and Drug Delivery", J. Am. Chem. Soc.2013, 135, 17617-17629 (SciBX).
10) J. M. Hu, T. Wu, G. Y. Zhang, S. Y. Liu*"Efficient Synthesis of Single Gold Nanoparticle Hybrid Amphiphilic Triblock Copolymers and Their Controlled Self-Assembly",J. Am. Chem. Soc. 2012,134, 7624-7627.
11) G. C. Yu, C. Y. Han, Z. B. Zhang, J. Z. Chen, X. Z. Yan, B. Zhang, S. Y. Liu*,F. H. Huang* "Pillar[6]arene-Based Photo-Responsive Host-Guest Complexation", J. Am. Chem. Soc.2012,134, 8711-8717.
12) C. H. Li, T. Wu, C. Y. Hong, G. Q. Zhang, S. Y. Liu*"A General Strategy to Construct Fluorogenic Probes from Charge-Generation Polymers (CGPs) and AIE-Active Fluorogens via Triggered Complexation",Angew. Chem. Int. Ed., 2012,51, 455-459.
13) C. H. Li, Y. X. Zhang, J. M. Hu, J. J. Cheng*, S. Y. Liu*,"Reversible Three-State Switching of Multicolor Fluorescence Emission via Multiple Stimuli-Modulated FRET Processes within Thermoresponsive Polymeric Micelles",Angew. Chem. Int. Ed., 2010,49, 5120-5124.
14) Z. S. Ge, Y. M. Zhou, J. Xu, H. W. Liu, D. Y. Chen*, S. Y. Liu*“High-Efficiency Preparation of Macrocyclic Diblock Copolymers via Selective Click Reaction in Micellar Media” J. Am. Chem. Soc.2009, 131, 1628-1629.
15) Z. S. Ge, J. M. Hu, F. H. Huang*, S. Y. Liu*“Responsive Supramolecular Gels Constructed via Crown Ether-Based Molecular Recognition” Angew. Chem. Int. Ed.2009, 48, 1798-1802.
16) J. Xu, Z. Y. Zhu, S. Z. Luo, C. Wu, S. Y. Liu* “First observation of two-stage collapsing kinetics of a single synthetic polymer chain” Phys. Rev. Lett. 2006, 96, 027802.
17) J. M. Hu, S. Y. Liu* “Engineering Responsive Polymer Building Blocks with Host-Guest Molecular Recognition for Functional Applications” Acc. Chem. Res.2014, 47, 2084-2095
18) J. M. Hu, G. Y. Zhang, Z. S. Ge, S. Y. Liu* “Stimuli-Responsive Tertiary Amine Methacrylate-Based Block Copolymers: Synthesis, Supramolecular Self-Assembly and Functional Applications” Prog. Polym. Sci. 2014, 39, 1096-1143.
19) Z. S. Ge*, S. Y. Liu* “Functional Block Copolymer Assemblies Responsive to Tumor and Intracellular Microenvironments for Site-Specific Drug Delivery and Enhanced Imaging Performance” Chem. Soc. Rev. 2013, 42, 7289-7325.
20) J. M. Hu, G. Q. Zhang, S. Y. Liu* “Enzyme-Responsive Polymeric Assemblies, Nanoparticles and Hydrogels” Chem. Soc. Rev. 2012, 41, 5933-5949.

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