Merger of C-F and C-N Bond Cleavage in Cross-Electrophile Coupling for the Synthesis of gem-Difluoroalkenes
2020-09-25
Organic Letters 22(14):5347-5352 Jul 2020 

Jin, Youxiang; Wu, Jiaoyang; Lin, Zhiyang; Lan, Yun; Wang, Chuan

Abstract:

Herein we successfully applied Katritzky salts as the alkyl electrophile in the reductive allylic defluorinative cross-coupling reaction with α-trifluoromethyl alkenes. The merger of C–F and C–N bond cleavage via the synergistic effect of nickel and zinc allows the efficient synthesis of diverse gem-difluoroalkenes with a good tolerance for various functional groups.

https://www.x-mol.com/paper/1276626844657414144?adv 


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