Acylation of Aryl Halides and alpha-Bromo Acetates with Aldehydes Enabled by Nickel/TBADT Cocatalysis
Organic Letters 22(10):3875-3878 May 2020 

Fan, Pei; Zhang, Chang; Zhang, Linchuan; Wang, Chuan


In this protocol aryl halides and α-bromo acetates are efficiently cross-coupled with an array of (hetero)aromatic and aliphatic aldehydes under the cooperative catalysis of nickel and tetrabutylammonium decatungstate as a hydrogen-atom-transfer photocatalyst. This method provides a concise approach to a variety of ketones with high compatibility of various functional groups. 

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