Name:Yongyan Chen
Address:443 Huangshan Street, Hefei City, Anhui 230027, P.R.China
Tel:0551-63600319
Fax:0551-63606783
E-mail:yychen08@ustc.edu.cn
EDUCATION AND RESEARCH EXPERIENCE
2009/2–presentAssociate Professor, Institute of Immunology, School of Life Science, Univ Sci Tech China (USTC)
2007/6–2009/2Postdoc, School of Life Science, USTC
2004/8–2007/6Ph.D., Immunology, School of Life Science, USTC
2001/8–2004/7M.S. , Shandong Acad Med Sci, China/ School of Life Science, USTC
1996/8–2001/7M.D., Shandong University, China
RESEARCH INTERESTS
1.Innate immunity in the liver;
2.Immune response and tolerance in HBV infection.
SELECTED PUBLICATIONS
1.Chen Y*, Hao X, Sun R, Wei H, Tian Z*.Natural Killer Cell-Derived Interferon-Gamma Promotes Hepatocellular Carcinoma Through the Epithelial Cell Adhesion Molecule-Epithelial-to-Mesenchymal Transition Axis in Hepatitis B Virus Transgenic Mice.Hepatology. 2018 Oct 17. doi: 10.1002/hep.30317.(*co-corresponding author)
2.Zeng Z, Li L, Chen Y, Wei H, Sun R, Tian Z. Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance. J Exp Med. 2016 May 30;213(6):1079-93.
3.Chen Y*, Sun R, Wu X, Cheng M, Wei H, Tian Z*. CD4+CD25+ Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis B Virus Transgenic Mice via Membrane-Bound TGF-β and OX40. J Innate Immun. 2016;8(1):30-42. (*co-corresponding author)
4.Tian Z, Chen Y, Gao B. Natural killer cells in liver disease. Hepatology. 2013 Apr; 57(4):1654-62.
5.Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology. 2007; 46(3):706-715.

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