Name:Tengchuan Jin
Address:Biomedical Building 303, Mid-campus
Tel:63600720
E-mail:jint@ustc.edu.cn
Lab website:http://tjlab.ustc.edu.cn/
EDUCATION AND RESEARCH EXPERIENCE
1998 - 2003B.S., Biological Sciences

University of Science and Technology of China, China
2003 - 2008Ph.D., Molecular Biochemistry and Biophysics

Illinois Institute of Technology, USA
2008 - 2012Post-doctoral Fellow, National Institute of Allergy and Infectious Diseases, NIH, USA
2012 - 2014Research Fellow, National Institute of Allergy and Infectious Diseases, NIH, USA
2015 – presentProfessor, University of Science and Technology of China (USTC)
RESEARCH INTERESTS
1.Structural biology of the innate immune system
2.Molecular mechanism of infectious diseases, particularly the microbe-host interactions
3.Molecular mechanism of inflammatory and autoimmune diseases
4.Protein engineering and protein drug discovery
SELECTED PUBLICATIONS
1.Jin T*,, Brefo. E, Fan W, Zeng W, Li Y, Zhang YZ, Palmer M (2018). Crystal structure of the Streptococcus agalactiae CAMP factor provides insights into its membrane-permeabilizing activity. J Biol Chem 293(30):11867-11877.
2.Li Y, Huang Y, Cao X, Yin X, Jin X, Liu S, Jiang J, Jiang W, Xiao TS, Zhou R, Cai G, Hu B, Jin T* (2018). Functional and Structural Characterization of Zebrafish ASC. FEBS J 285(14):2691-2707.
3.Jin T*, Wang C, Zhang CY, Wang Y, Chen YW, Guo F, Howard A, Cao MJ, Fu TJ, McHugh TH, Zhang YZ* (2017) Crystal Structure of Cocosin, A Potential Food Allergen from Coconut 
(Cocos nucifera). J Agric Food Chem 65(34): 7560-7568.
4.Cao X#, Li YJ#*, Jin X, Li YL, Guo F, Jin T* (2017). Molecular Mechanism of Divalent-Metal-Induced Activation of NS3 Helicase and Insights into Zika Virus Inhibitor Design. Nucleic Acids Res 44(21): 10505-10514.
5.Chuenchor W#, Jin T#, Ravilious G, Xiao TS* (2014). Structures of pattern recognition receptors reveal molecular mechanisms of autoinhibition, ligand recognition and oligomerization.Curr Opin Immunol 26:14-20. (#co-first author, invited review).
6.Sirois CM#, Jin T#, Miller AL, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Brewah Y, Tian J, Chang C, Schowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS*, Latz E * (2013) RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. J Exp Med 210: 2447-2463. (#co-first author). Highlighted in the November 2013 issue of Nature Structural & Molecular Biology.
7.Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam V, Hornung V, Johnstone RW, Latz E, Bowie AG, Fitzgerald KA, Xiao TS (2012) Structures of The HIN domain:DNA complexes reveal ligand binding and activation mechanisms of The AIM2 inflammasome and IFI16. Immunity 36(4): 561-571



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