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Name:Ruan, Ke
Address:443 Huangshan Road, Hefei, Anhui 230027 China
Tel:+86-551-63607767
E-mail:kruan@ustc.edu.cn
EDUCATION AND RESEARCH EXPERIENCE
2011/01 till nowAssociate Professor, School of Life Sciences, USTC
2010/02-2010/12Staff Scientist, DDU, Beatson Institute, CRUK
2008/05-2010/02Postdoctoral research fellow, St Louis R&D, Pfizer Inc
2002/09–2008/05Ph. D. Johns Hopkins University
1999/09–2002/07M. S. College of Chemistry and Molecular Engineering, Peking University
1995/09–1999/07B. S. College of Chemistry and Molecular Engineering, Peking University
RESEARCH INTERESTS
1.Fragment-based lead discovery, NMR methodology
SELECTED PUBLICATIONS
1.Jia Gao#, E Liang#, Rongsheng Ma, Fudong Li, Yixiang Liu, Jiuyang Liu, Ling Jiang, Conggang Li, Haiming Dai, Jihui Wu, Xuncheng Su, Wei He, Ke Ruan*, Fluorine Pseudocontact Shifts Used for Characterizing the protein-Ligand Interaction Mode in the Limit of NMR Intermediate Exchange, Angew. Chem. Int. Ed., 2017, 56(42): 12982-12986
2.Difei Xu#, Rongsheng Ma, Jiahai Zhang, Zhijun Liu, Bo Wu, Junhui Peng, Yanan Zhai, Qingguo Gong, Yunyu Shi, Jihui Wu, Qiang Wu, Zhiyong Zhang*, Ke Ruan*, Dynamic Nature of CTCF Tandem 11 Zinc Fingers in Multivalent Recognition of DNA As Revealed by NMR Spectroscopy, J. Phys. Chem. Lett., 2018 9(14): 4020-4028
3.Difei Xu#, Bin Li#, Jia Gao#, Zhijun Liu, Xiaogang Niu, Gilbert Nshogoza, Jiahai Zhang, Jihui Wu, Xun-Cheng Su, Wei He, Rongsheng Ma*, Daiwen Yang*, Ke Ruan*, Ligand Proton Pseudocontact Shifts Determined from Paramagnetic Relaxation Dispersion in the Limit of NMR Intermediate Exchange, J. Phys. Chem. Lett., 2018, 9(12): 3361-3367
4.Jiuyang Liu#, Shuya Zhang#, Mingqing Liu, Yaqian Liu, Gilbert Nshogoza, Jia Gao, Rongsheng Ma, Yang Yang, Jihui Wu, Jiahai Zhang*, Fudong Li*, Ke Ruan*, Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit, FEBS J. 2018, 285(11): 2091-2103
5.Rongsheng Ma#, Qingfeng Li, Aidong Wang, Jiahai Zhang, Zhijun Liu, Jihui Wu, Xuncheng Su*, Ke Ruan*, Determination of pseudocontact shifts of low-populated excited states by NMR chemical exchange saturation transfer, Phys. Chem. Chem. Phys. 2016, 18(20): 13794-13798



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