Name:Zhiyong ZHANG
Address:University of Science & Technology of China
Tel:86-551-63600854
E-mail:zzyzhang@ustc.edu.cn
EDUCATION AND RESEARCH EXPERIENCE
06/2010 – presentProfessor, School of Life Sciences, University of Science and Technology of China
04/2010 – 12/2010Postdoctoral Scholar, Department of Chemistry, University of Chicago
12/2006 – 03/2010Postdoctoral Fellow, Department of Chemistry, University of Utah
12/2003 – 12/2006Postdoctoral Fellow, School of Health Information Sciences, University of Texas Health Science Center at Houston
09/1998 – 07/2003School of Life Sciences, University of Science and Technology of China Ph.D. in Biochemistry and Molecular Biology
09/1994 – 07/1998Department of Biology, University of Science and Technology of China B.S. in Molecular and Cell Biology
RESEARCH INTERESTS
1.Computational tools for multi-scale modeling of large biomolecules, such as sampling techniques in molecular dynamics simulations and coarse-grained methods
2.Multi-scale modeling to investigate functional dynamics of biomolecules by integrating structural data from various experiments including NMR, cryo-electron microscopy (cryo-EM), and small-angle X-ray scattering (SAXS)
SELECTED PUBLICATIONS
1.Difei Xu, Rongsheng Ma, Jiahai Zhang, Zhijun Liu, Bo Wu, Junhui Peng, Yanan Zhai, Qingguo Gong, Yunyu Shi, Jihui Wu, Qiang Wu, Zhiyong Zhang*, Ke Ruan*. Dynamic nature of CTCF tandem 11 zinc fingers in multivalent recognition of DNA as revealed by NMR Spectroscopy. The Journal of Physical Chemistry Letters 2018 (9): 4020-4028
2.Bin Wen, Weiwei Wang, Jiahai Zhang, Qingguo Gong, Yunyu Shi, Jihui Wu*, Zhiyong Zhang*. Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies. Physical Chemistry Chemical Physics 2017 (19): 21152-21164
3.Peng Cheng#, Junhui Peng#, Zhiyong Zhang*. SAXS-oriented ensemble refinement of flexible biomolecules. Biophysical Journal 2017 (112): 1295-1301
4.Junhui Peng, Zhiyong Zhang*. Unraveling low-resolution structural data of large biomolecules by constructing atomic models with experiment-targeted parallel cascade selection simulations. Scientific Reports 2016 (6): 29360
5.Yonghui Zhang, Junhui Peng, Zhiyong Zhang*. Structural modeling of proteins by integrating small-angle X-ray scattering data. Chinese Physics B 2015 (24): 126101
6.Junhui Peng, Debiao Zhao, Bin Wen, Zhiyong Zhang*. Determining structural models of biomolecular complexes integrating nuclear magnetic resonance, small-angle X-ray scattering and computational simulations. Chinese Journal of Magnetic Resonance 2015 (32): 181-194
7.Yonghui Zhang, Bin Wen, Junhui Peng, Xiaobing Zuo, Qingguo Gong, Zhiyong Zhang*. Determining structural ensembles of flexible multi-domain proteins using small-angle X-ray scattering and molecular dynamics simulations. Protein & Cell 2015(6): 619-623
8.Zhiyong Zhang*. Systematic methods for defining coarse-grained maps in large biomolecules. Advances in Structural Bioinformatics 2015 (827): 33-48
9.Bin Wen#, Junhui Peng#, Xiaobing Zuo, Qingguo Gong, Zhiyong Zhang*. Characterization of protein flexibility using small-angle X-ray scattering and amplified collective motion simulations. Biophysical Journal 2014 (107): 956-964
10.Junhui Peng, Zhiyong Zhang*. Simulating large-scale conformational changes of proteins by accelerating collective motions obtained from principal component analysis. Journal of Chemical Theory and Computation 2014 (10): 3449-3458
11.Debiao Zhao, Xuejuan Wang, Junhui Peng, Chongyuan Wang, Fudong Li, Qianqian Sun, Yibo Zhang, Jiahai Zhang, Gang Cai, Xiaobing Zuo, Jihui Wu, Yunyu Shi, Zhiyong Zhang*, Qingguo Gong*. Structural investigation of the interaction between the tandem SH3 domains of c-Cb1-associated protein and vinculin. Journal of Structural Biology 2014 (187): 194-205

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