Name:Linfeng Sun
Address:Life science building, USTC, Hefei, Anhui
Tel:0551-63606932
E-mail:sunlf17@ustc.edu.cn
EDUCATION AND RESEARCH EXPERIENCE
2005-2009B.S., Department of Biological Sciences and Biotechnology,Tsinghua University
2009-2014Ph.D., School of Life Sciences, Tsinghua University
2014-2017Research associate (postdoctoral fellow), School of Life Sciences, Tsinghua University
2017-PresentProfessor, School of Life Sciences, University of Science and Technology of China
RESEARCH INTERESTS
Focus on the structural and mechanistic studies of important membrane proteins and complexes, especially those closely related to essential cellular processes and human diseases, using mainly cryo-EM and X-ray crystallography methods.
REPRESENTATIVE PUBLICATIONS
1.Liu X, Wang J#, Sun L#. (2018). Structure of the hyperosmolality-gated calcium permeable channel OSCA1.2. Nature Communications, 9(1):5060. (#, corresponding author)
2.Sun L*, Zhou R*, Yang G*, Shi Y. (2017). Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by-secretase.Proceedings of the National Academy of Sciences of the United States of America, 114(4), E476-E485. (*, co-first author)
3.Sun L, Li X, Shi Y. (2016). Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to-secretase.Current Opinion in Structural Biology, 37, 97–107.
4.Sun L*, Zhao L*, Yang G*, Yan C*, Zhou R*, Zhou X, Xie T, Zhao Y, Wu S, Li X, Shi Y. (2015). Structural basis of human γ-secretase assembly.Proceedings of the National Academy of Sciences of the United States of America, 112(19), 6003-6008. (*, co-first author)
5.Madej MG*,Sun L*, Yan N, Kaback HR. (2014). Functional architecture of MFS D-glucose transporters.Proceedings of the National Academy of Sciences of the United States of America, 111(7), E719-727. (*, co-first author)
6.Sun L*, Zeng X*, Yan C, Sun X, Gong X, Rao Y, Yan N. (2012). Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature, 490(7420), 361-366. (*, co-first author)
7.Dang S, Sun L*, Huang Y*, Lu F, Liu Y, Gong H, Wang J, Yan N. (2010). Structure of a fucose transporter in an outward-open conformation. Nature, 467(7316), 734-738. (*, co-author)



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