Name:Zhenhua Gu
Address:Department of Chemistry, University of Science and Technology of

China, No. 96 Jinzhai Road,  Hefei, Anhui, P. R. China. 230026
Tel:+86-0551-63600069
E-mail:zhgu@ustc.edu.cn
EDUCATION AND RESEARCH EXPERIENCE
2012.1-NowProfessor, University of Science and Technology of China, Department of Chemistry
2008.8-2011.12Postdoctoral Fellow, University of California, Santa Barbara
2007.8-2008.7Postdoctoral Fellow, University of California, Berkeley
2002.9-2007.6Ph.D. Shanghai Institute of Organic Chemistry
1998.9-2002.6B.A. Nanjing University
RESEARCH INTERESTS
Natural products synthesis is one of the major research interests of our group. Complex molecule synthesis not only serves for the further biological and medicinal studies, but also provides new question and promotes the innovation of synthetic methods. Our group is interested in development of simple, novel methods and strategies that enable C-C, C-heteroatom bond formations and functionalization of unsaturated carbon-carbon bonds, and finally these new developed methods would be used in the total synthesis of highly functionalized natural products.
REPRESENTATIVE PUBLICATIONS
1.Enhanced Reactivity by Torsional Strain of Cyclic Diaryliodonium in Cu-Catalyzed Enantioselective Ring-Opening Reaction, Kun Zhao†, Longhui Duan†, Shibo Xu, Julong Jiang, Yao Fu*, and Zhenhua Gu*(Lead Contact), Chem, 2018, 4, p 599–612. This work was highlighted by X-Mol, DOI:10.1016/j.chempr.2018.01.017 (K. Z. and L. D. contributed equally).
2.Cu-Catalyzed Enantioselective Ring Opening of Cyclic Diaryliodoniums toward the Synthesis of Chiral Diarylmethanes, Bin Li, Zengyin Chao, Chunyu Li, Zhenhua Gu*, J. Am. Chem. Soc., 2018, 140 (30), pp 9400–9403. DOI:10.1021/jacs.8b05743.
3.Enantioselective Synthesis of Biaryl Atropisomers via Pd/Norbornene-Catalyzed Three-Component Cross-Couplings, Linlin Ding, Xianwei Sui, Zhenhua Gu*, ACS Catal., 2018, 8, pp 5630–5635, DOI:10.1021/acscatal.8b01037
4.Unusual Biaryl Torsional Strain Promoted Reactivity in Cu-Catalyzed Sommelet-Hauser Rearrangement, Chongqing Pan, Wenjing Guo, Zhenhua Gu*Chem. Sci., 2018, 9, 5850-5854. DOI:10.1039/C8SC01657G
5.Palladium-Catalyzed Enantioselective Synthesis of 2-Aryl Cyclohex-2-enone Atropisomers: Platform Molecules for the Divergent Synthesis of Axially Chiral Biaryl Compounds, Chongqing Pan, Zixi Zhu, Mingkai Zhang, Zhenhua Gu*, Angew. Chem. Int. Ed. 2017, 56, 4777–4781, DOI:10.1002/anie.201701467.
6.Cleavage of the C(O)–S Bond of Thioesters by Palladium/Norbornene/Copper Cooperative Catalysis: An Efficient Synthesis of 2-(Arylthio)aryl Ketones, Fenggang Sun, Miao Li, Congfa He, Bin Wang, Bin Li, Xianwei Sui, Zhenhua Gu*, J. Am. Chem. Soc., 2016, 138 (24), pp 7456–7459, DOI:10.1002/anie.201509571.
7.Enantioselective Synthesis of Atropisomeric Vinyl Arene Compounds by Palladium Catalysis: A Carbene Strategy, Jia Feng†, Bin Li†, Yun He, Zhenhua Gu*, Angew. Chem. Int. Ed. 2016, 55, 2186–2190, DOI:10.1002/anie.201509571 (J. F. and B. L. contributed equally).
8.Palladium-Catalyzed Catellani ortho-Acylation Reaction: An Efficient and Regiospecific Synthesis of Diaryl Ketones,Yunze Huang, Rui Zhu, Kun Zhao, Zhenhua Gu*, Angew. Chem., Int. Ed. 2015, 54, 12669-12672. DOI:10.1002/anie.201506446.
9.Palladium-Catalyzed Intramolecular Asymmetric C-H Functionalization/Cyclization Reaction of Metallocenes: An Efficient Approach toward the Synthesis of Planar Chiral Metallocene Compounds, Ruixian Deng,† Yunze Huang,† Xinna Ma, Gencheng Li, Rui Zhu, Bin Wang, Yan-Biao Kang,* and Zhenhua Gu*, J. Am. Chem. Soc. 2014, 136, 4472-4475, DOI: 10.1021/ja500699x.(R. D. and Y. H. contributed equally)
10.Pd-Catalyzed Chemoselective Catellani Ortho-Arylation of Iodopyrroles: Rapid Total Synthesis of Rhazinal,Xianwei Sui, Rui Zhu, Gencheng Li, Xinna Ma, and Zhenhua Gu*J. Am. Chem. Soc. 2013, 135, 9318-9321,DOI: 10.1021/ja404494u. This work was highlighted by Synlett 2013, 24, 2023-2031, DOI: 10.1055/s-0033-1339756. (X. S. and R. Z. contributed equally)



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