Name:Sun Rui (孙汭)
Address:School of Life Science, University of Science and Technology of

China, Hefei, Anhui 230027, P. R. China
03/1978-12/1982Bachelor of Medicine, Shanxi Medical University, China
09/1997-06/2000M.S., Immunology, Normal Bethune Med Univ, Changchun, China
1985.10-2001.03Assistant/Associate/Full Professor, Shandong Acad Med Sci, China
1995.09-1996.09Visiting Scientist, NCI, NIH, USA
2001.03-2002.03Visiting Scientist, NCI, NIH, USA
2002.04-2006.03Visiting Scientist, NIAAA, NIH, USA
2006.06-presentProfessor, University of Science and Technology of China
We are attempting to study the roles of innate immune receptors in NK cells- or NKT cells-mediated liver injury and diseases. Currently, we are elucidating how the PAMPs induce the ligand expression of hepatic parenchymal cells and hepatic non-parenchymal cells such as Kupffer cells, Sttellet cells and liver sinusoid endothelial cells, which may be recognized by receptors of NK cells or NKT cells as the stressed signals or danger signals. The cellular and molecular mechanisms of PAMPs-induced interaction between lymphoid cells and non-lymphoid cells and their pathological importance in liver diseases are investigated.
We are studying the roles of NK cell receptors such as NCRs, NKG2 family, KIRs, SLAMs and DNAMs in synapse formation between NK cells and targets. The integrated signals and balance of inhibitory and stimulatory receptors in immune synapse formation and function are also interested.

1.Wang X, Peng H*, Cong J, Wang X, Lian Z, Wei H, Sun R*,Tian Z*.Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis. Nat. Commun. Published: 19 November 2018.
2.Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, SunR*, Tian Z*. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nature Immunology. 2018 Jun 18;723–732 .
3.Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*, Tian Z*. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice. J Hepatol. 2015 Jan, 62(6):1311-1318.
4.Cao G, Wang J, Zheng X, Wei H, Tian Z, Sun R*. Tumor therapeutics work as stress inducers to enhance tumor sensitivity to NK cell cytolysis by upregulating NKp30 ligand B7-H6. J Biol Chem. 2015 Oct 15;290(50):29964-29973
5.Deng G, Zheng X, Zhou J, Wei H, Tian Z, Sun R*. Generation and preclinical characterization of an NKp80-Fc fusion protein for redirected cytolysis of NK cells against leukemia. J Biol Chem. 2015 Sep 11;290(37):22474-84.
6.Wang W, Guo H, Geng J, Zheng X, Wei H, Sun R*, Tian Z*. Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack. J Biol Chem. 2014 Nov 28; 289 (48):33311-9.
7.Bi J, Zheng X, Chen Y, Wei H, Sun R*, Tian Z*. TIGIT safeguards liver regeneration through regulating natural killer cell-hepatocyte crosstalk. Hepatology. 2014 Oct; 60(4):1389-98.
8.Bi J, Zhang Q, Liang D, Xiong L, Wei H, Sun R*, Tian Z*. T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis. Hepatology. 2014 May; 59(5):1715-25.
9.Geng J, Wang X, Wei H, Sun R*, Tian Z*. Efficient attenuation of NK cell-mediated liver injury through genetically manipulating multiple immunogenes by using a liver-directed vector. J Immunol. 2013 May 1;190(9):4821-9.
10.Wang X, Sun R*, Wei H, Tian Z*. High-mobility group box 1 (HMGB1)-Toll-likereceptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: Interaction of γδ T cells with macrophages. Hepatology. 2011 Jan; 57(1):373-84.

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