LIU Qiang, Professor, Young Thousand Talents ProgramNeural Circuitry and Cognition
Name: Qiang Liu(刘强)
Address:School of Life Sciences,
University of Science and Technology of China
443 Huangshan Street, Hefei City, Anhui 230027, P.R.China
 2012 - presentProfessor, School of Life Sciences, University of Science & Technology of China
 2011 - 2012Research Associate, Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
 2005 - 2010

Postdoc Fellow, Department of Pediatrics Department of Cell Biology and physiology, Washington University School of Medicine

 2000 - 2005Ph.D, Institute of Biophysics, Chinese Academy of Sciences

 1996 - 2000

B.S., Department of Biochemistry, Shandong University

 One of the central questions in Neuroscience is how the brain learns, receives and stores information as memory. My laboratory is interested in elucidating the physiological mechanisms underlying learning and memory, and also pathogenic mechanisms underlying neurological disorders affecting learning and memory,such as Alzheimer’s Disease. To achieve this, we’re combining multidisciplinary tools to investigate the processes underlying learning and memory in molecular, cellular, circuit and animal levels. Specifically, we’re exploring 1) how lipid metabolism in the brain affects learning and memory in both physiological and pathological conditions; 2) whether the non-coding RNA network is involved in the regulation of learning and memory; 3) the relationship between brain energy homeostasis and learning and memory.
1)Berg MG, Singh LN, Younis I, Liu Q, Pinto AM, Kaida D, Zhang Z, Cho S, Sherrill-Mix S, Wan L, Dreyfuss G. U1 snRNP Determines mRNA Length and Regulates Isoform Expression. Cell. 150: 53-64, 2012.
2)Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G. Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biology. 9(1): e1000575, 2011.
3)Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1. Neuron 56:66-78, 2007.
4)Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A, 104:10613-10618, 2007.
5)Jacob CO, Eisenstein M, Dinauer MC, Ming W, Liu Q, John S, Quismorio FP Jr, Reiff A, Myones BL, Kaufman KM, McCurdy D, Harley JB, Silverman E, Kimberly RP, Vyse TJ, Gaffney PM, Moser KL, Klein-Gitelman M, Wagner-Weiner L, Langefeld CD, Armstrong DL, Zidovetzki R. Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proc Natl Acad Sci U S A, 109:E59-67,2012. 
6)Liu Q, Zhang J, Trotter J, Cheng C, Han X, Weeber EJ, Bao J, Herz J, Bu G. Lipoprotein receptor LRP1 regulates age-dependent synaptic and neuronal degeneration by modulating brain lipid metabolism. J. Neurosci. 30:17068-17078. 2010.
7)Kanekiyo T, Zhang J, Liu Q, Liu CC, Zhang L, Bu G. Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-{beta} Uptake. J.Neurosci. 31: 1644-1651, 2011.
8)Liu Q, Zhang J, Zhu H, Qin C, Chen Q, Zhao B. Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. FASEB J 21:61-73, 2007.
9)Zhang J, Liu Q, Chen Q, Liu NQ, Li FL, Lu ZB, Qin C, Zhu H, Huang YY, He W, Zhao BL. Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis. FASEB J 20:1212-1214, 2006.
10)Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S, Bu G. LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Mol Neurodegener. 4:17, 2009.
11)Zhang J, Li Y, Liu Q, Lu W, Bu G. Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis. Oncogene. 29:539-549, 2010.
12)Fuentealba R*, Liu Q*, Zhang J, Kanekiyo T, Bu G. Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal A{lower case beta}42 uptake and lysosomal accumulation. PLoS ONE. 5: e11884. 2010.(* Co-first author)
13)Liu Q, Zhao B. Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. Br J Pharmacol. 141:746-754, 2004.
14)Liu Q, Tao Y, Zhao BL. ESR study on scavenging effect of nicotine on free radicals. Appl. Magn. Reson. 24,105-112, 2003.
15)Fuentealba RA, Liu Q, Kanekiyo T, Zhang J, Bu G. Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J Biol Chem. 284:34045-34053, 2009.
16)Liu Q*, Zhang J. Lipid metabolism in Alzheimer's disease. Neurosci Bull. 30:331-45, 2014.(*corresponding author)
17)Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T.The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. J Biol Chem. 283:34554-34562, 2008.
18)Parkyn CJ, Vermeulen EG, Mootoosamy RC, Sunyach C, Jacobsen C, Oxvig C, Moestrup S, Liu Q, Bu G, Jen A, Morris RJ. LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein. J Cell Sci. 121:773-783, 2008.
19)Grear KE, Ling IF, Simpson JF, Furman JL, Simmons CR, Peterson SL, Schmitt FA, Markesbery WR, Liu Q, Crook JE, Younkin SG, Bu G, Estus S. Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Mol Neurodegener. 4:46, 2009.
20)Jen A, Parkyn CJ, Mootoosamy RC, Ford MJ, Warley A, Liu Q, Bu G, Baskakov IV, Moestrup S, McGuinness L, Emptage N, Morris RJ. Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4. J Cell Sci. 123:246-255, 2010.

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