Name:Qiang Liu(刘强)
Address:School of Life Sciences

University of Science & Technology of China,

443 Huangshan Street, Hefei City, Anhui 230027
2012 - presentProfessor, School of Life Sciences, University of Science & Technology of China
2011 - 2012Research Associate, Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
2005 - 2010Postdoc Fellow, Department of Pediatrics Department of Cell Biology and physiology,Washington University School of Medicine
2000 - 2005Ph.D, Institute of Biophysics, Chinese Academy of Sciences
1996 - 2000B.S., Department of Biochemistry, Shandong University
One of the central questions in Neuroscience is how the brain learns, receives and stores information as memory. My laboratory is interested in elucidating the physiological mechanisms underlying learning and memory, and also pathogenic mechanisms underlying neurological disorders affecting learning and memory,such as Alzheimer’s Disease. To achieve this, we’re combining multidisciplinary tools to investigate the processes underlying learning and memory in molecular, cellular, circuit and animal levels. Specifically, we’re exploring 1) how brain  lipid metabolism affects learning and memory in both physiological and pathological conditions; 2) how the epigenetic regulation is involved in learning and memory; 3) the relationship between brain energy homeostasis and learning and memory.
1.Li D, Zhang J, Wang M, Li X, Gong H, Tang H, Chen L, Wan L and Liu Q. Activity dependent LoNA Regulates Translation by Coordinating rRNA Transcription and Methylation. Nat Commun. 9(1):1726,2018.
2.Berg MG, Singh LN, Younis I, Liu Q, Pinto AM, Kaida D, Zhang Z, Cho S, Sherrill-Mix S, Wan L, Dreyfuss G. U1 snRNP Determines mRNA Length and Regulates Isoform Expression. Cell. 150: 53-64, 2012.
3.Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1. Neuron 56:66-78, 2007.
4.You L, Wang J, Liu T, Zhang Y, Han X, Wang T, Guo S, Dong T, Xu J, Anderson GJ, Liu Q, Chang YZ, Lou X, Nie G Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice. ACS Nano. 12(5):4123-4139, 2018.
5.Zhang J, Liu Q. Cholesterol metabolism and homeostasis in the brain. Protein Cell. 6(4):254-64,2015.
6.Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G. Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biology. 9(1): e1000575, 2011.
7.Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A, 104:10613-10618, 2007.
8.Liu Q, Zhang J, Trotter J, Cheng C, Han X, Weeber EJ, Bao J, Herz J, Bu G. Lipoprotein receptor LRP1 regulates age-dependent synaptic and neuronal degeneration by modulating brain lipid metabolism. J. Neurosci. 30:17068-17078. 2010.
9.Kanekiyo T, Zhang J, Liu Q, Liu CC, Zhang L, Bu G. Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-{beta} Uptake. J.Neurosci. 31: 1644-1651, 2011.
10.Liu Q, Zhang J, Zhu H, Qin C, Chen Q, Zhao B. Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. FASEB J 21:61-73, 2007.
11.Zhang J, Liu Q, Chen Q, Liu NQ, Li FL, Lu ZB, Qin C, Zhu H, Huang YY, He W, Zhao BL. Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis. FASEB J 20:1212-1214, 2006.
12.Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S, Bu G. LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Mol Neurodegener. 4:17, 2009.
13.Zhang J, Li Y, Liu Q, Lu W, Bu G. Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis. Oncogene. 29:539-549, 2010.
14.Fuentealba RA, Liu Q, Kanekiyo T, Zhang J, Bu G. Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J Biol Chem. 284:34045-34053, 2009.
15.Liu Q*, Zhang J. Lipid metabolism in Alzheimer's disease. Neurosci Bull. 30:331-45, 2014.

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