Name:SONG Xiaoyuan (宋晓元)
Address:School of Life Sciences,

University of Science and Technology of China,

230026 Hefei, P. R. China
Tel:+86 551 63607752
Dr. Xiaoyuan Song obtained bachelor and master degrees from Beijing Normal University in 1996 and 1999, respectively. In 2006, she obtained Ph. D degree in Molecular, Cellular and Developmental Biology from the Department of Biology, University of Rochester, USA. She went on for postdoctoral training at the University of California, San Diego from 2006 to 2012 with fellowship from CRI (Cancer Research institute).  Dr. Song Joined USTC as a professor in Dec. 2012.
We aim to investigate the role of three-dimensional transcriptional regulation composed of long noncoding RNA (lncRNA) and three-dimensional genome structure in brain aging and spermatogenesis. A three-dimensional model to regulate transcription by chromatin interactions mediated by lncRNAs was proposed (Protein cell 2015), which will be verified in the process of brain aging and other life processes. We reported the first three-dimensional genome structures for both macronucleus and micronucleus in the single-cell eukaryotic model animal Tetrahymena thermophila, and the mechanism of the formation of macronuclear chromosomes (Genome Research 2020). The function of the master player Cyc2 in upstream of meiosis in Tetrahymena was analyzed (protein cell 2016), and the dynamic changes of three-dimensional genome structure during spermatogenesis in mice was also revealed. We also collaboratively discovered the function of conserved lncRNA clusters (CNIB1) in development and vision (NAR 2019).
1.Roles of three-dimensional transcriptional regulation orchestrated by lncRNAs and chromatin interaction/structure in brain aging.
2.To investigate the role of lncRNAs and chromatin interaction/structure in the process of spermatogenesis.
3.To study the function and molecular mechanism of key genes in meiosis.
1.Luo Z.*, Hu T. *, Jiang H., Wang R., Xu Q., Zhang S., Cao J., Song X.#. Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila. Genome Research. 2020. Mar 12. doi: 10.1101/gr.241687.118. #Corresponding author.
2.Cheng Q.*, Ouyang X.*, Zhang R.*, Zhu L., Song X.#. Senescence-associated genes and non-coding RNAs function in pancreatic cancer progression. RNA Biology. 2020. Jan 30: 1-14. #Corresponding author.
3.Cao J., Jiang H.*, Zhang R.*, Ghanam AR.*, Xia H., Zhu Y., Yang Z., Song X.#. Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance. Science Bulletin. 2019. 64: 1132-1135. #Corresponding author.
4.Ghanam AR., Cao J., Ouyang X., and Song X.#. New insights into chronological mobility of retrotransposable elements in vivo. Oxidative Medicine and Cellular Longevity. 2019. 2818415. eCollection 2019. #Corresponding author.
5.Wang F.*, Ren D.*, Liang X.*, Ke S., Zhang B., Hu B.#, Song X.#, Wang X.#. A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic Acids Research. 2019, 47(12): 6315-6329. #Corresponding author.
6.Mamun M.Al., Mannoor K., Cao J., Qadri F., Song X.#. SOX2 in cancer stemness: Tumor malignancy and therapeutic potentials. Journal of Molecular Cell Biology. 2018. doi: 10.1093/jmcb/mjy080. #Corresponding author.
7.Ghanam AR., Xu Q., Ke Sh., Azhar M., Cheng Q., Song X.#. Shining the light on senescence associated lncRNAs. Aging & Disease. 2017, 1; 8(2):149-161. #Corresponding author.
8.Xu Q., Wang R., Ghanam AR., Yan G., Miao W., Song X.#. The key role of CYC2 during meiosis in Tetrahymena thermophila. Protein & Cell. 2016, 7(4):236-49. #Corresponding author.
9.Cao J., Luo Z., Cheng Q., Xu Q., Zhang Y., Wang F., Wu Y., Song X.#. Three-dimensional regulation of transcription. Protein & Cell. 2015, 6(4):241-53. #Corresponding author.
10.Song X., Bowen J., Miao W., Liu Y., and Gorovsky MA.#. The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation. Genes & Development. 2012, 26(6):615-29.
11.Song X.*, Wang X.*, Arai S. and Kurokawa R.#. Promoter-associated noncoding RNA from the CCND1 promoter. Methods in Molecular Biology. 2012, 809:609-22. *Co-first author.
12.Harismendy O.*, Notani D.*, Song X., Rahim NG., Tanasa B., Heintzman N., Ren B., Fu XD., Topol EJ., Rosenfeld MG#, and Frazer KA#. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011, 470(7333):264-8. *Co-first author.
13.Wang X.* and Song X.*, Glass CK., and Rosenfeld MG#. The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs. Cold Spring Harb Perspect Biol. 2011 3(1):a003756. *Co-first author. Collected in《The RNA World》IV.
14.Wang X., Arai S.*, Song X.*, Reichart D., Du K., Pascual G., Tempst P., Rosenfeld MG.#, Glass CK.#, and Kurokawa R.#. Induced ncRNAs allosterically modify RNA binding proteins in cis to inhibit transcription. Nature. 2008, 454(7200):126-30.
15.Song, X.*, Gjoneska E.*, Ren Q.*, Taverna SD., Allis C.D., and Gorovsky MA.#. Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila. Mol Cell Biol. 2007, 27(7):2648-60. *Co-first author.
16.Song X. and Gorovsky MA.#. Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2 is down-regulated during starvation. Mol Cell Biol. 2007, 27(5):1925-33.
17.Shang Y., Song X., Bowen J., Corstanje R., Gao Y., Gaertig J., and Gorovsky MA.#. A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. PNAS. 2002, 99(6):3734-9.

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