Name:CAI Gang (蔡刚)
Address:No. 443 Huangshan Rd, Hefei, Anhui, China, 230027

School of Life Science, University of

Science & Technology of China
Tel:86-551-63603802
E-mail:gcai@ustc.edu.cn
EDUCATION AND RESEARCH EXPERIENCE
2010.11-presentProfessor, University of Science and Technology
2006.03-2010.11Research Associate, the Scripps Research Institute, USA
2001.09-2006.03Ph.D. Shanghai Institutes for Biological Sciences
1997.09-2001.07B.S. Anhui University B.S. in Microbiology, 2001
RESEARCH INTERESTS
I am interested in examining the structures and functional interactions of key macromolecular complexes responsible for regulation of chromatin structure and genomic stability, aiming at a structural understanding of the molecular mechanism and designing novel pharmaceuticals for cancer therapy.
REPRESENTATIVE PUBLICATIONS
1.Wang, X., Ran, T., Zhang, X., Xin, J., Zhang, Z., Wu, T., Wang, W. and Cai, G*. (2017) 3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. Science, 358, 1206-1209.
2.Wang, X*., Ahmad, S., Zhang, Z., Côté, J., Cai, G*. (2018) Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. Nature communications, 9, 1147
3.Zhang, Z., Wang, X*., Xin, J., Ding, Z., Liu, S., Fang, Q., Yang, N., Xu, R., Cai, G*. (2018) Architecture of SWI/SNF chromatin remodeling complex. Protein Cell, 9, 1045-1049
4.Zhang, X., Wang, X*., Zhang, Z., and Cai, G*. (2019) Structure and Functional Interactions of INO80 Actin/Arp Module. J Mol Cell Biol. (doi: 10.1093/jmcb/mjy062)
5.Wang, X., Chu, H., Lv, M., Zhang, Z., Qiu, S., Liu, H., Shen, X., Wang, W*., Cai, G*. (2016) Structure of the intact ATM/Tel1 kinase. Nature communications 7, 11655
6.Ma, R., Qiu, S., Jiang, Q., Sun, H., Xue, H., Cai, G.,* and Sun, B.* (2017) AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus, International Journal of Medical Microbiology, 06, 307(4–5): 257~267
7.Wang, X., Sun, Q., Ding, Z., Ji, J., Wang, J., Kong, X., Yang J.H., and Cai, G.* (2014) Redefining the Modular Organization of the Core Mediator Complex. Cell Research 24, 796-808 (Cover story)
8.Wang, X., Wang, J., Ding, Z., Ji, J., Sun, Q., and Cai, G.* (2013) Structural flexibility and functional interaction of mediator Cdk8 module, Protein & Cell,12.4, 4(12): 911~920

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