Name:Jianye Zang (臧建业)
Address:School of life science, University of Science and Technology of 

China, Hefei, Anhui 230027, P. R. China
1994-1998Bachelor, University of Science and Technology of China, China
1998-2003Ph. D, University of Science and Technology of China, China
2003-2007Post-doctoral fellow, National Jewish Medical and Research Center, UCHSC, USA
2007- PresentProfessor, University of Science and Technology of China, China
1.Regulation and function of histone modifications
2.Molecular mechanism of kinetochore assembly
3.Structural and functional studies of Staphylococcus aureusvirulence factors
1.Structural basis of writing, reading and erasing histone modifications, Ministry of Science & Technology of China
2.Molecular basis and function of kinetochore assembly, National Natural Science Foundation of China
3.Structural biological research of Staphylococcus aureus virulence factors, National Natural Science Foundation of China
1.Hang, T., Chen, W., Wu, M., Zhan, L., Wang, C., Jia, N., Zhang, X and Zang, J. (2019) Structural insights into the molecular mechanism underlying Sirt5-catalyzed desuccinylation of histone peptides, Biochem J 476, 211-223.
2.Fang, T., Chen, W., Sheng, Y., Yuan, S., Tang, Q., Li, G., Huang, G., Su, J., Zhang, X., Zang, J. and Liu, Y. (2019) Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein, Nature commun 10, 186.
3.Wang, C., Zhan, L., Wu, M., Ma, R., Yao, J., Xiong, Y., Pan, Y., Guan, S., Zhang, X. and Zang, J. (2018) Spindlin-1 recognizes methylations of K20 and R23 of histone H4 tail, FEBS lett 592, 4098-4110.
4.Chen, X., Wang, C., Zhang, X., Tian, T. and Zang, J. (2018) Crystal structures of the N-terminal domain of the Staphylococcus aureus DEAD-box RNA helicase CshA and its complex with AMP, Acta Crystallogr F Struct Biol Commun 74, 704-709.
5.Tian, T., Wang, C., Wu, M., Zhang, X. and Zang, J. (2018) Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion, Biochemistry 57, 4252-4262.
6.Tian, T., Li, X., Liu, Y., Wang, C., Liu, X., Bi, G., Zhang, X., Yao, X., Zhou, Z. H., and Zang, J. (2018) Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore, Cell Res 28, 374-378.
7.Hang, T., Zhang, X., Wu, M., Wang, C., Ling, S., Xu, L., Gong, Q., Tian, C., Zhang, X. and Zang, J. (2018) Structural insights into a novel functional dimer of Staphylococcus aureus RNase HII, Biochem Biophys Res Commun 503, 1207-1213.
8.Zhou, X., Zheng, F., Wang, C., Wu, M., Zhang, X., Wang, Q., Yao, X., Fu, C., Zhang, X. and Zang, J. (2017) Phosphorylation of CENP-C by Aurora B facilitates kinetochore  attachment error correction in mitosis, Proc Natl Acad Sci USA 114, E10667-E10676.
9.Zhang, Y., Wu, M., Hang, T., Wang, C., Yang, Y., Pan, W., Zang, J., Zhang, M., and Zhang, X. (2017) Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion, Biochem J 474, 1619-1631.
10.Wang, X., Wang, C., Wu, M., Tian, T., Cheng, T., Zhang, X. and Zang, J. (2017) Enolase binds to RnpA in competition with PNPase in Staphylococcus aureus, FEBS lett. 591, 3523-3535.
11.Li, Y., Chen, X. B., Jia, N., Zhang, X. and Zang, J.(2017) Identification of Set11 from Staphylococcus aureus Mu50 strain as a ortholog of SSL7 via bioinformatic analysis   and determination of its possible targets from human serum using CNBr-pull down assays, Biotechnol Lett 39, 1413-1423.
12.Chen, W., Wu, M., Hang, T., Wang, C., Zhang, X. and Zang, J. (2017) Structure insights into the molecular mechanism of the interaction between UHRF2 and PCNA,  Biochem Biophys Res Commun 494, 575-580.
13.Wang C, Zhang Q, Hang T, Tao Y, Ma X, Wu M, Zhang X and Zang J. (2015). Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8. Acta Crystallogr D BiolCrystallogr 71:1955-64.
14.Song Y, Zhang F, Li X, Zang J. and Zhang X. (2015). Crystallographic studies of SarV, a global regulator from Staphylococcus aureus. Acta Crystallogr F Struct Biol Commun 71:1038-41.
15.Zhang W, Wang C, Song Y, Shao C, Zhang X. and Zang J. (2015). Structural insights into the mechanism of Escherichia coli YmdB: A 2'-O-acetyl-ADP-ribose deacetylase. J Struct Biol 192:478-86.
16.Wu Y, Wang C, Lin S, Wu M, Han L, Tian C, Zhang X and Zang J. (2015). Octameric structure of Staphylococcus aureus enolase in complex with phosphoenolpyruvate. Acta Crystallogr D BiolCrystallogr 71(Pt 12):2457-2470.
17.Shao, C., Wang, C. and Zang, J. (2014). Structural basis for the substrate selectivity of PvuRts1I, a 5-hydroxymethylcytosine DNA restriction endonuclease. Acta Crystallogr D Biol Crystallogr 70, 2477-86.
18.Wang, J., Liu, X., Dou, Z., Chen, L., Jiang, H., Fu, C., Fu, G., Liu, D., Zhang, J., Zhu, T., Fang, J., Zang, J., Cheng, J., Teng, M., Ding, X. and Yao, X. (2014). Mitotic regulator Mis18beta interacts with and specifies the centromeric assembly of molecular chaperone holliday junction recognition protein (HJURP). J Biol Chem 289, 8326-36
19.Tao, Y., Wu, M., Zhou, X., Yin, W., Hu, B., de Crombrugghe, B., Sinha, K.M. and Zang, J. (2013) Structural Insights into Histone Demethylase NO66 in Interaction with Osteoblast-specific Transcription Factor Osterix and Gene Repression. J Biol Chem, 288, 16430-16437.
20.Sun, D., Liu, Q., He, Y., Wang, C., Wu, F., Tian, C. and Zang, J. (2013). The putative propeptide of MycP1 in mycobacterial type VII secretion system does not inhibit protease activity but improves protein stability. Protein Cell 4, 921-31.
21.Wu, M., Tao, Y., Liu, X. and Zang, J. (2013) Structural Basis for Phosphorylated Autoinducer-2 Modulation of the Oligomerization State of the Global Transcription Regulator LsrR from Escherichia coli. J Biol Chem, 288, 15878-15887.
22.Zhang, X., Chen, J., Wu, M., Wu, H., Arokiaraj, A.W., Wang, C., Zhang, W., Tao, Y., Huen, M.S. and Zang, J. (2013) Structural basis for role of ring finger protein RNF168 RING domain. Cell Cycle, 12, 312-321.
23.Ruan, J., Xu, C., Bian, C., Lam, R., Wang, J.P., Kania, J., Min, J. and Zang, J. (2012) Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1. FEBS Lett, 586, 314-318.
24.Li, J., Wang, C., Wu, Y., Wu, M., Wang, L., Wang, Y. and Zang, J. (2012) Crystal structure of Sa239 reveals the structural basis for the activation of ribokinase by monovalent cations. J Struct Biol, 177, 578-582.
25.Bian, C., Xu, C., Ruan, J., Lee, K. K., Burke, T. L., Tempel, W., Barsyte, D., Li, J., Wu, M., Zhou, B. O., Fleharty, B. E., Paulson, A., Allali-Hassani, A., Zhou, J. Q., Mer, G., Grant, P. A., Workman, J. L.*, Zang, J.* & Min, J.* (2011). Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J 30, 2829-42. (*Co-corresponding author)
26.Wang, L., Wu, M. & Zang, J. (2011). Crystal structure of Sa240: A ribose pyranase homolog with partial active site from Staphylococcus aureus. J Struct Biol 174, 413-9.
27.Hong, X.*, Zang, J.*, White, J.*, Wang, C., Pan, C. H., Zhao, R., Murphy, R. C., Dai, S., Henson, P., Kappler, J. W., Hagman, J. & Zhang, G. (2010). Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci USA 107, 14568-72. (*Co-first author)
28.Liu, Y., Huang, H., Zhou, B. O., Wang, S. S., Hu, Y., Li, X., Liu, J., Zang, J., Niu, L., Wu, J., Zhou, J. Q., Teng, M. & Shi, Y. (2010). Structural analysis of Rtt106p reveals a DNA binding role required for heterochromatin silencing. J Biol Chem 285, 4251-62.
29.Lai, C., Wu, M., Li, P., Shi, C., Tian, C. & Zang, J. (2010). Solution NMR characterization of Sgf73(1-104) indicates that Zn ion is required to stabilize zinc finger motif. Biochem Biophys Res Commun 397, 436-40.
30.Wang, J., Zhang, W., Song, W., Wang, Y., Yu, Z., Li, J., Wu, M., Wang, L., Zang, J. & Lin, Q. (2010). A biosynthetic route to photoclick chemistry on proteins. J Am Chem Soc 132, 14812-8.
31.Zhu, Z., Gao, Y., Yu, Y., Zhang, X., Zang, J., Teng, M. & Niu, L. (2009). Structural basis of the autolysis of AaHIV suggests a novel target recognizing model for ADAM/reprolysin family proteins. Biochem Biophys Res Commun 386, 159-64.
32.Chen, Z., Zang, J., Kappler, J., Hong, X., Crawford, F., Wang, Q., Lan, F., Jiang, C., Whetstine, J., Dai, S., Hansen, K., Shi, Y. & Zhang, G. (2007). Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci USA 104, 10818-23.
33.Chen, Z.*, Zang, J.*, Whetstine, J., Hong, X., Davrazou, F., Kutateladze, T. G., Simpson, M., Mao, Q., Pan, C. H., Dai, S., Hagman, J., Hansen, K., Shi, Y. & Zhang, G. (2006). Structural insights into histone demethylation by JMJD2 family members. Cell 125, 691-702. (*Co-first author)
34.Wang, D., Guo, M., Liang, Z., Fan, J., Zhu, Z., Zang, J., Li, X., Teng, M., Niu, L., Dong, Y. & Liu, P. (2005). Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites. J Biol Chem 280, 22962-7.

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